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Clinical Article
Analysis of resting-state voxel-mirrored homotopic connectivity in severe obstructive sleep apnea
SHEN Guo  ZHANG Huiyan  GAO Jing  WU Dan  HUANG Gang  ZHANG Wenwen  ZHAO Lianping 

Cite this article as: SHEN G, ZHANG H Y, GAO J, et al. Analysis of resting-state voxel-mirrored homotopic connectivity in severe obstructive sleep apnea[J]. Chin J Magn Reson Imaging, 2023, 14(11): 12-17, 61. DOI:10.12015/issn.1674-8034.2023.11.003.

[Abstract] Objective To utilize the resting-state functional magnetic resonance imaging technology to explore the changes of voxel-mirrored homotopic connectivity (VMHC) in patients with severe obstructive sleep apnea (OSA).Materials and Methods A total of fifty patients with OSA and fifty healthy controls, matched in terms of age, sex, and education, were included in this study. The data of clinical situations, neuropsychological scale assessment and brain magnetic resonance imaging of all participants were further collected. VMHC and the seed-based functional connectivity (FC) were calculated and compared between these two groups. Additionally, Pearson correlation analysis was conducted to examine the relationship between the significant brain areas for VMHC and FC, and the clinical variables and neuropsychological scale scores.Results Compared to control group, patients with severe OSA exhibited lower cognitive scores, and higher depression and anxiety scores. In patients with OSA, the VMHC of the bilateral calcarine and the bilateral superior parietal gyrus was significantly decreased. The FC was found to be abnormal in the bilateral lingual gyrus, right middle occipital gyrus, and left middle temporal gyrus (gaussian random field correction, voxel level P<0.001, cluster level P<0.05). The VMHC value of bilateral calcarine gyrus in severe OSA patients showed a negative correlation with the apnea hypopnea index (r=-0.31, P=0.027), and a positive correlation with mean blood oxygen saturation (SaO2) (r=0.30, P=0.033). Additionally, the VMHC value of the bilateral superior parietal gyrus was positively correlated with the mean and minimum SaO2 (r=0.29, P=0.039; r=0.31, P=0.028). Furthermore the FC value between the left superior parietal gyrus and the angle gyrus was positively correlated with the mean SaO2 (r=0.29, P=0.041).Conclusions Cognitive function impairment and potential risk of depression and anxiety are observed in severe OSA patients. The alteration of interhemispheric coordination and abnormal FC of the bilateral calcarine and the bilateral superior parietal gyrus may be significant neuropathological mechanisms contributing to cerebral impairments in patients with OSA.
[Keywords] obstructive sleep apnea;resting state magnetic resonance imaging;voxel-mirrored homotopic connectivity;functional connectivity;cognitive dysfunction;emotional abnormalities

SHEN Guo1, 2   ZHANG Huiyan1, 2   GAO Jing3   WU Dan3   HUANG Gang2   ZHANG Wenwen2   ZHAO Lianping2*  

1 School of Clinical Medicine, Ningxia Medical University, Yinchuan 750004, China

2 Department of Radiology, Gansu Provincial Hospital, Lanzhou 730099, China

3 The First Clinical Medical College, Gansu University of Chinese Medicine, Lanzhou 730000, China

Corresponding author: ZHAO L P, E-mail:

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 81901724); Natural Science Foundation of Gansu Province (No. 21JR7RA593).
Received  2023-06-27
Accepted  2023-10-27
DOI: 10.12015/issn.1674-8034.2023.11.003
Cite this article as: SHEN G, ZHANG H Y, GAO J, et al. Analysis of resting-state voxel-mirrored homotopic connectivity in severe obstructive sleep apnea[J]. Chin J Magn Reson Imaging, 2023, 14(11): 12-17, 61. DOI:10.12015/issn.1674-8034.2023.11.003.

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