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Clinical Article
A study of altered resting state and dynamic functional connectivity characteristics of the hippocampus bilaterally in first-episode depression
CAO Jiudong  WANG Xiaoling  ZHANG Lei  HONG Yang  ZHANG Guolei  BAO Yan  LUO Ping  SUN Li  HAN Ming  LÜ Xueyu  LIU Jun  YAO Xiaoyan  LI Shanshan  SUN Jifei  FANG Jiliang 

Cite this article as: CAO J D, WANG X L, ZHANG L, et al. A study of altered resting state and dynamic functional connectivity characteristics of the hippocampus bilaterally in first-episode depression[J]. Chin J Magn Reson Imaging, 2023, 14(10): 7-11, 30. DOI:10.12015/issn.1674-8034.2023.10.002.

[Abstract] Objective To observe bilateral hippocampal static state and dynamic functional connectivity (dFC) features and association with clinical symptoms in first episode depression (FDE).Materials and Methods Twenty-six FDE patients (FDE group) and 20 healthy controls (HCs group) were retrospectively included. rs-fMRI scans were performed on the two groups of subjects, and after using the bilateral hippocampus as the seed point, the resting state functional connectivity (sFC) and dynamic functional connectivity (dFC) differences between the two groups were observed. The differences of sFC and dFC between the two groups were observed, and the clinical depression scale of FDE patients was completed to analyze the correlation between the different brain regions and clinical symptoms.Results Compared with the HCs group, the sFC of the left hippocampus with the right orbitofrontal middle gyrus was decreased in the FDE group, and the sFC of the right hippocampus with the right precentral gyrus was decreased. Compared with the HCs group, the dFC of the left hippocampus with the right supplementary motor area and the right precentral gyrus was decreased in the FDE group, and the dFC of the right hippocampus with the left precentral gyrus was decreased and increased with the dFC of the right inferior occipital gyrus. Correlation analysis revealed a positive correlation between dFC values in the right hippocampus with the right suboccipital gyrus and 24-item Hamilton Rating Scale for Depression, scores in the FDE group (r=0.474, P=0.015).Conclusions The presence of abnormal alterations in the sFC of the hippocampus and reward network and sensorimotor network bilaterally with abnormal alterations in the dFC of the sensorimotor network and visual processing cortex in FDE patients provides some implications for understanding the neuropathological mechanisms and targeted therapies in FDE patients.
[Keywords] first-episode depression;resting-state functional magnetic resonance imaging;magnetic resonance imaging;hippocampus;state functional connectivity;dynamic functional connectivity

CAO Jiudong1   WANG Xiaoling1*   ZHANG Lei1   HONG Yang1   ZHANG Guolei1   BAO Yan1, 2   LUO Ping1   SUN Li1   HAN Ming1   LÜ Xueyu1   LIU Jun1   YAO Xiaoyan1   LI Shanshan1   SUN Jifei1   FANG Jiliang1  

1 Department of Radiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China

2 Department of Radiology, Dalian Branch of Shengjing Hospital Affiliated to China Medical University, Dalian 116600, China

Corresponding author: WANG X L, E-mail:

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 81303056); Science and Technology Innovation Project of China Academy of Chinese Medical Sciences (No. CI2021A03304, CI2021A03312, CI2021A03106)
Received  2023-06-09
Accepted  2023-09-27
DOI: 10.12015/issn.1674-8034.2023.10.002
Cite this article as: CAO J D, WANG X L, ZHANG L, et al. A study of altered resting state and dynamic functional connectivity characteristics of the hippocampus bilaterally in first-episode depression[J]. Chin J Magn Reson Imaging, 2023, 14(10): 7-11, 30. DOI:10.12015/issn.1674-8034.2023.10.002.

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