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Advances in diffusion MRI based on oscillating gradient spin echo
ZHANG Xinli  WANG Jing 

ZHANG X L, WANG J. Advances in diffusion MRI based on oscillating gradient spin echo[J]. Chin J Magn Reson Imaging, 2023, 14(9): 198-202. DOI:10.12015/issn.1674-8034.2023.09.036.

[Abstract] Diffusion magnetic resonance imaging (dMRI) is one of the most promising methods for microstructural imaging of biological tissues, which has made great progress in tumor and neuroimaging. Oscillating gradient spin echo (OGSE) sequence is a new dMRI technique, which shortens the measurable effective diffusion time of water molecules by applying oscillating gradients. By establishing a mathematical model, the microstructure characteristics such as cell diameter, extracellular water molecular diffusion coefficient, intracellular water molecular volume fraction and cellularity can be measured. It shows the prospect of clinical application in tumor cell diameter measurement, tumor heterogeneity evaluation and nerve axon diameter measurement. This paper reviewed the imaging principle of OGSE, the research status of OGSE in tumors and nerve axons, and the current limitations of OGSE, aiming to provide reference for scholars interested in this technology, promote further research on OGSE, and accelerate the application of OGSE in clinical diagnosis and treatment.
[Keywords] diffusion magnetic resonance imaging;microstructure imaging;oscillating gradient spin echo;tumor imaging;neuroimaging

ZHANG Xinli1, 2   WANG Jing1, 2*  

1 Department of Radiology, Union hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China

2 Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430030, China

Corresponding author: Wang J, E-mail:

Conflicts of interest   None.

ACKNOWLEDGMENTS Natural Science Foundation of Hubei Province (No. 2021CFB447).
Received  2023-05-06
Accepted  2023-07-27
DOI: 10.12015/issn.1674-8034.2023.09.036
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