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Research status and progress in the application of MRI quantitative techniques in osteoporosis
ZHOU Feng  LÜ Furong 

ZHOU F, LÜ F R. Research status and progress in the application of MRI quantitative techniques in osteoporosis[J]. Chin J Magn Reson Imaging, 2023, 14(9): 192-197. DOI:10.12015/issn.1674-8034.2023.09.035.

[Abstract] Osteoporosis, as a systemic skeletal metabolic disease, is characterized by low bone mass and deterioration of microstructure, which makes an individual more likely to fracture. Bone mineral density (BMD) has been the gold standard for clinically diagnosing osteoporosis and predicting the risk of fracture. However, MRI techniques are becoming increasingly important in the study of etiology, diagnosis and fracture risk of osteoporosis because of the higher tissue resolution, non-invasive and non-radiation, and the availability of information on bone quality except BMD. Compared with BMD alone, magnetic resonance spectroscopy and water-lipid separation techniques can accurately quantify the bone marrow adipose, diffusion-weighted imaging reflects the pathophysiological changes of bone marrow by assessing the diffusion properties of bone marrow tissue, high-resolution MRI can better predict osteoporotic fractures by microstructural analysis of proximal femoral trabeculae, and ultrashort echo time MRI reflects bone strength by detecting the binding water and pore water content of cortical bone. The paper reviews the application of MRI quantitative techniques in the diagnosis of osteoporosis, summarises their principles and application value, and analyses their advantages and disadvantages, with a view to providing a reference for future applications and studies related to the quantitative assessment of bone quality by MRI and the comprehensive assessment of osteoporosis progression by combined bone mineral density.
[Keywords] osteoporosis;quantitative techniques;magnetic resonance imaging;magnetic resonance spectroscopy;water-fat separation technology;diffusion-weighted imaging;high-resolution magnetic resonance imaging

ZHOU Feng   LÜ Furong*  

Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

Corresponding author: Lü FY, E-mail:

Conflicts of interest   None.

Received  2023-03-06
Accepted  2023-07-21
DOI: 10.12015/issn.1674-8034.2023.09.035
ZHOU F, LÜ F R. Research status and progress in the application of MRI quantitative techniques in osteoporosis[J]. Chin J Magn Reson Imaging, 2023, 14(9): 192-197. DOI:10.12015/issn.1674-8034.2023.09.035.

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