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Clinical Article
Changes of cerebrospinal fluid capacity in patients with lung cancer with or without chemotherapy and its clinical significance
ZHAO Qiuyue  LIANG Xue  RONG Ping  CHEN Wenqian  MA Yiming  HAN Xiaowei 

ZHAO Q Y, LIANG X, RONG P, et al. Changes of cerebrospinal fluid capacity in patients with lung cancer with or without chemotherapy and its clinical significance[J]. Chin J Magn Reson Imaging, 2023, 14(9): 33-38. DOI:10.12015/issn.1674-8034.2023.09.006.

[Abstract] Objective To explore the effects of lung cancer (LC) and chemotherapy on the total amount of intracranial cerebrospinal fluid (CSF) and the volume of CSF in various subregions in patients with LC by using both horizontal and vertical analysis methods.Materials and Methods In the horizontal study, 151 cases of patient with LC admitted to our hospital from May 2019 to December 2021 were retrospectively analyzed, of which 38 receivied chemotherapy. Meanwhile, 39 healthy controls (HC) were recruited. The differences of total CSF volume and CSF capacity in each subregion were compared among the three groups by one-way ANOVA. Then the correlations between the significantly different indicators and cancer-related clinical data in each group were carried out. In the longitudinal study, an additional 20 cases of LC patients admitted to our hospital between July 2020 and January 2022 were then retrospectively analyzed. The paired t-test method was used to compare the changes in CSF volume between the two times, and then, the correlation analyses were performed between the significantly different indexes and the follow-up interval.Results In the transverse study, the CSF volume in the third ventricle and right lateral ventricle of LC patients with chemotherapy and without chemotherapy were significantly higher than that of the HC group (P<0.05). And in the chemotherapy group, the tumor size was positively correlated with the CSF in the third ventricle (P<0.05). The longitudinal study showed that compared with the first brain scan, the volume of intracranial, peripheral and left lateral ventricle CSF in LC patients increased significantly after the second follow-up (P<0.05). And the CSF differences above were positively associated with the follow-up interval (P<0.05).Conclusions LC and chemotherapy lead to aberrant CSF volume in multiple ventricles,which may provide a new neuroimaging marker for LC diagnosis and assist in guiding cancer chemotherapy.
[Keywords] lung cancer;chemotherapy-related brain injury;cerebrospinal fluid;three-dimensional T1 weighted imaging;magnetic resonance imaging;cross-sectional study;longitudinal study

ZHAO Qiuyue   LIANG Xue   RONG Ping   CHEN Wenqian   MA Yiming   HAN Xiaowei*  

Department of Medical Imaging, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China

Corresponding author: Han XW, E-mail:

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 82171908).
Received  2023-03-24
Accepted  2023-08-04
DOI: 10.12015/issn.1674-8034.2023.09.006
ZHAO Q Y, LIANG X, RONG P, et al. Changes of cerebrospinal fluid capacity in patients with lung cancer with or without chemotherapy and its clinical significance[J]. Chin J Magn Reson Imaging, 2023, 14(9): 33-38. DOI:10.12015/issn.1674-8034.2023.09.006.

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