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Application progress of diffusion-weighted imaging basded on mono-exponential and intravoxel incoherent motion imaging in autoimmune diseases
TIAN Manting  DING Changwei 

TIAN M T, DING C W. Application progress of diffusion-weighted imaging basded on mono-exponential and intravoxel incoherent motion imaging in autoimmune diseases[J]. Chin J Magn Reson Imaging, 2023, 14(8): 158-164. DOI:10.12015/issn.1674-8034.2023.08.028.

[Abstract] Diffusion weighted imaging (DWI) is a non-invasive method to detect the micro movement of water molecules in human body. Apparent diffusion coefficient (ADC) of mono-exponential DWI can be used for quantitative evaluation of the direction and degree of restriction in the diffusion motion of water molecules, which indirectly reflected the changes and characteristics of microstructure in the organization. However, the result is a superposition of both pure water molecules and perfusion-related diffusion. Bi-exponential DWI, also called intravoxel incoherent motion (IVIM) imaging is based on mono-exponential DWI, a kind of multi-b DWI, which can distinguish the diffusion of pure water molecules and perfusion-related diffusion precisely. Due to their high sensitivity to microstructure changes, mono-exponential DWI and IVIM imaging have important application value in diagnosis of disease, evaluation of disease activity and prognosis, providing effective imaging evidence for clinical, therefore conventional DWI and IVIM imaging are being used more and more widely in autoimmune diseases. The author reviewed the application progress of mono-exponential DWI and IVIM imaging in autoimmune encephalitis, autoimmune hepatitis, autoimmune pancreatitis, ankylosing spondylitis, immune nephropathy and Takayasu arteritis, aimed to elaborate the current situation and progress of their application in autoimmune diseases and further explore the prospects and shortcomings of their extensive application in autoimmune diseases.
[Keywords] autoimmune diseases;magnetic resonance imaging;diffusion weighted imaging;intravoxel incoherent motion imaging

TIAN Manting   DING Changwei*  

Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110004, China

Corresponding author: Ding CW, E-mail:

Conflicts of interest   None.

ACKNOWLEDGMENTS Natural Science Foundation of Liaoning Province (No. 20170541045).
Received  2022-10-24
Accepted  2023-06-15
DOI: 10.12015/issn.1674-8034.2023.08.028
TIAN M T, DING C W. Application progress of diffusion-weighted imaging basded on mono-exponential and intravoxel incoherent motion imaging in autoimmune diseases[J]. Chin J Magn Reson Imaging, 2023, 14(8): 158-164. DOI:10.12015/issn.1674-8034.2023.08.028.

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