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Advances in multimodal MRI studies of brain network changes in subjective cognitive decline
WEI Zeyi  LI Xiaoling  CAO Danna  WANG Liqin  WANG Yang  HOU Yu  HAN Shengwang  GAO Shenglan  LU Xinyu 

WEI Z Y, LI X L, CAO D N, et al. Advances in multimodal MRI studies of brain network changes in subjective cognitive decline[J]. Chin J Magn Reson Imaging, 2023, 14(8): 129-134. DOI:10.12015/issn.1674-8034.2023.08.022.

[Abstract] Subjective cognitive decline (SCD) is an early stage of Alzheimer's disease (AD), the main symptom is a decline in self-perceived memory, and the incidence is on the rise. Therefore, preventing or delaying the progression of SCD is critical. In recent years, with the continuous development of multimodal MRI and brain network analysis techniques, scholars have evaluated whether the structure and density of brain networks are complete by studying and observing the changes of neurons and nerve fiber bundles in the brains of patients with SCD. In this paper, structural MRI , diffusion tensor imaging and functional MRI are reviewed. Based on the structural and functional brain network characteristics of SCD disease, the brain network changes and pathophysiological mechanisms of SCD disease were explored from multiple perspectives to find biomarkers and analyze the existing deficiencies, so as to provide help for the early diagnosis and treatment of SCD.
[Keywords] subjective cognitive decline;structural brain network;functional brain network;structural magnetic resonance imaging;diffusion tensor imaging;functional magnetic resonance imaging;multimodal;magnetic resonance imaging

WEI Zeyi1   LI Xiaoling2   CAO Danna2   WANG Liqin3*   WANG Yang2   HOU Yu4   HAN Shengwang5   GAO Shenglan1   LU Xinyu1  

1 Graduate School, Heilongjiang University of Chinese Medicine, Harbin 150040, China

2 Department of CT Magnetic Resonance, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, China

3 Department of Nursing Teaching and Research, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, China

4 Department of Gynecology, Harbin Hospital of Traditional Chinese Medicine, Harbin 150020, China

5 Department of Rehabilitation, the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150001, China

Corresponding author: Wang LQ, E-mail:

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 82074537); Natural Science Foundation Project of Heilongjiang Province (No. LH2020H103, LH2021H101); Scientific Research Project of Heilongjiang Administration of Traditional Chinese Medicine (No. ZHY2022-194); Heilongjiang Traditional Chinese Medicine Outstanding Innovative Talents Program (No. 2018RCD02).
Received  2023-06-01
Accepted  2023-08-04
DOI: 10.12015/issn.1674-8034.2023.08.022
WEI Z Y, LI X L, CAO D N, et al. Advances in multimodal MRI studies of brain network changes in subjective cognitive decline[J]. Chin J Magn Reson Imaging, 2023, 14(8): 129-134. DOI:10.12015/issn.1674-8034.2023.08.022.

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