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The value of MRI IVIM in identifying hepatocellular carcinoma and intrahepatic cholangiocarcinoma
WANG Xi  FENG Su  LI Hong  XU Jingxing  HU Shuang  WANG Shen 

Cite this article as: WANG X, FENG S, LI H, et al. The value of MRI IVIM in identifying hepatocellular carcinoma and intrahepatic cholangiocarcinoma[J]. Chin J Magn Reson Imaging, 2023, 14(7): 49-52, 85. DOI:10.12015/issn.1674-8034.2023.07.009.

[Abstract] Objective To explore the value of MRI intravoxel incoherence motion (IVIM) in differentiating hepatocellular carcinoma (HCC) from intrahepatic cholangiocarcinoma (ICC).Materials and Methods This study included 60 patients with malignant hepatic nodules. All patients underwent IVIM scans on a 3.0 T MRI scanner. The slow apparent diffusion (Dslow), fast diffusion coefficient (Dfast), perfusion fraction (f), distributed diffusion coefficient (DDC) and water diffusion heterogeneity index (α) were obtained. Receiver operating characteristic (ROC) curve analysis was used to compare the efficacy of each parameter in differentiating HCC from ICC.Results The Dslow and DDC values of lesions in the HCC group were significantly lower than in the ICC group (all P<0.05), the Dfast of lesions in the HCC group were significantly higher than in the ICC group, f and α values did not statistically differ between the HCC and ICC groups. When the cut-off values of Dslow, Dfast and DDC were 0.88×10-3 mm2/s, 20.82×10-3 mm2/s, and 1.30×10-3 mm2/s, respectively, and the sensitivity was 94.1%, 82.4%, 82.4%, the specificity was 72.1%, 65.1%, 67.4%, and the area under the curve (AUC) was 0.846, 0.756 and 0.803, respectively.Conclusions The biexponential model and the stretched exponential model can be used to differentiate HCC from ICC, and the Dslow had the highest diagnostic efficiency.
[Keywords] hepatocellular carcinoma;intrahepatic cholangiocarcinoma;differential diagnosis;magnetic resonance imaging;intravoxel incoherence motion;biexponential model;stretched model

WANG Xi   FENG Su   LI Hong*   XU Jingxing   HU Shuang   WANG Shen  

Department of Radiology, Affiliated Renhe Hospital of China Three Gorges University, Yichang 443001, China

Corresponding author: Li H, E-mail:

Conflicts of interest   None.

Received  2022-09-10
Accepted  2023-06-25
DOI: 10.12015/issn.1674-8034.2023.07.009
Cite this article as: WANG X, FENG S, LI H, et al. The value of MRI IVIM in identifying hepatocellular carcinoma and intrahepatic cholangiocarcinoma[J]. Chin J Magn Reson Imaging, 2023, 14(7): 49-52, 85. DOI:10.12015/issn.1674-8034.2023.07.009.

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