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ASL in childhood brain tumors: A Meta-analysis
GUO Yu  SHAO Jianbo  PENG Xuehua  XIA Wei 

Cite this article as: GUO Y, SHAO J B, PENG X H, et al. ASL in childhood brain tumors: A Meta-analysis[J]. Chin J Magn Reson Imaging, 2023, 14(7): 25-31. DOI:10.12015/issn.1674-8034.2023.07.005.

[Abstract] Objective To assess the diagnostic accuracy of arterial spin labeling (ASL) in the differentiation of high-grade and low-grade brain tumors in children based on Meta-analysis.Materials and Methods Comprehensive search of studies from January 2011 to November 2022 in CNKI, Wanfang Data, MEDLINE (Ovid), Pubmed, Embase, Web of Science and Cochrane Library (Wiley) databases. Data extraction and quality assessment of the retrieved studies were performed according to inclusion and exclusion criteria. Stata 16 and RevMan 5.3 were used for Meta-analysis.Results Eleven articles were included, and the diagnostic data were absolute cerebral blood flow and relative cerebral blood flow. The mean difference in aCBF was 24.39 mL/min/100 g [95% confidence interval (CI): 3.56-45.22 mL/min/100 g], I2=88%, P<0.00001; the mean difference in rCBF was 0.92 mL/min/100 g (95% CI: 0.80-1.04 mL/min/100 g), I2=40%, P=0.112. The pooled sensitivity for aCBF was 90% (95% CI: 69%-97%), specificity was 87% (95% CI: 70%-95%), the area under the curve was 0.95 (95% CI: 0.92-0.96), the pooled sensitivity for rCBF was 90% (95% CI: 84%-94%), the specificity was 92% (95% CI: 86%-96%), and the area under the curve was 0.96 (95% CI: 0.94-0.98).Conclusions ASL showed high diagnostic accuracy for distinguishing high-grade brain tumors from low-grade brain tumors in children, and can be used as a potential method for grading brain tumors in children. Relative cerebral blood flow showed less variation among studies than absolute cerebral blood flow.
[Keywords] brain tumors;arterial spin labeling;magnetic resonance imaging;children;Meta-analysis

GUO Yu   SHAO Jianbo*   PENG Xuehua   XIA Wei  

Department of Imaging Center, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan Clinical Research Center for Children's Medical Imaging, Wuhan 430015, China

Corresponding author: Shao JB, E-mail:

Conflicts of interest   None.

ACKNOWLEDGMENTS Natural Science Foundation of Hubei Province (No. 2021CFB177); Wuhan Municipal Health Commission-Clinical Medical Scientific Research Project (No. WX21Z64).
Received  2023-02-17
Accepted  2023-06-25
DOI: 10.12015/issn.1674-8034.2023.07.005
Cite this article as: GUO Y, SHAO J B, PENG X H, et al. ASL in childhood brain tumors: A Meta-analysis[J]. Chin J Magn Reson Imaging, 2023, 14(7): 25-31. DOI:10.12015/issn.1674-8034.2023.07.005.

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