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Research progress on the application of 4D-ASL in cerebrovascular disease
LIN Xiaoyi  ZHANG Zongli 

Cite this article as: LIN X Y, ZHANG Z L. Research progress on the application of 4D-ASL in cerebrovascular disease[J]. Chin J Magn Reson Imaging, 2023, 14(6): 113-118. DOI:10.12015/issn.1674-8034.2023.06.020.

[Abstract] Four dimensional arterial spin labeling (4D-ASL) can achieve whole-brain perfusion imaging, selective single-vessel or whole-body cerebral vascular dynamic imaging in a non-invasive way without exogenous contrast agent, and achieve similar digital subtraction angiography effect, providing the hemodynamics and collateral circulation of cerebrovascular disease (CVD), benefiting patients with gadolinium contrast allergy and renal insufficiency, especially for children and patients with long-term follow-up. 4D-ASL has high temporal and spatial resolution, and has broad application prospects in CVD, which is helpful to analyze the characteristics of disease, such as the display of collateral circulation in arterial stenosis and occlusive disease and moyamoya disease; the measurement of aneurysm body; shunt location of arteriovenous fistula, identification of feeding artery and Borden classification; characteristics and auxiliary treatment of arteriovenous malformations. 4D-ASL is gradually becoming the next generation of non-invasive angiography technology. However, there are few research reports on 4D-ASL, and scholars lack understanding of 4D-ASL. Therefore, this article provides an overview of the imaging principles of 4D-ASL and its application value in CVD, in order to prospect the development and research direction of 4D-ASL. For scholars interested in this technology to reference and further research based on it, accelerating 4D-ASL to become a routine method for CVD vascular imaging examination.
[Keywords] arterial spin labeling;four dimensional arterial spin labeling;four dimensional arterial spin labeling magnetic resonance angiography;magnetic resonance imaging;cerebrovascular disease

LIN Xiaoyi1, 2   ZHANG Zongli1*  

1 Department of Radiology, Chenjiaqiao Hospital, Shapingba District, Chongqing, Chongqing 401331, China

2 School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China

Corresponding author: Zhang ZL, E-mail:

Conflicts of interest   None.

ACKNOWLEDGMENTS Joint Medical Scientific Research Project of Shapingba District Bureau of Science and Technology and Health Commission of Chongqing (No. 2021SQKWLH009); 2022 Shapingba District Decision-making Consultation and Management Innovation Project of Chongqing Shapingba District Bureau of Science and Technology (No. jcd202221); School-level Project Fund of Chongqing Medical and Pharmaceutical College (No. ygz2021131).
Received  2022-07-30
Accepted  2023-04-28
DOI: 10.12015/issn.1674-8034.2023.06.020
Cite this article as: LIN X Y, ZHANG Z L. Research progress on the application of 4D-ASL in cerebrovascular disease[J]. Chin J Magn Reson Imaging, 2023, 14(6): 113-118. DOI:10.12015/issn.1674-8034.2023.06.020.

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