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Clinical Article
Brain regional homogeneity alterations in multi-frequency bands in primary dysmenorrhea: A resting-state functional magnetic resonance imaging study
LIU Ni  ZHANG Ya'nan  DAI Na  HUO Jianwei  ZHANG Lei  HUANG Yiran  LIU Junlian 

Cite this article as: LIU N, ZHANG Y N, DAI N, et al. Brain regional homogeneity alterations in multi-frequency bands in primary dysmenorrhea: A resting-state functional magnetic resonance imaging study[J]. Chin J Magn Reson Imaging, 2023, 14(6): 39-44. DOI:10.12015/issn.1674-8034.2023.06.006.

[Abstract] Objective To investigate whether the spontaneous regional neural activity abnormalities in patients with primary dysmenorrhea (PDM) are associated with specific frequency bands using a multifrequency bands regional homogeneity (ReHo) method and to explore whether the alteration of ReHo values is associated with clinical measures.Materials and Methods Thirty-two PDM patients and thirty-six healthy controls (HC) were enrolled in this study and underwent resting-state functional magnetic resonance imaging. The ReHo analyses in conventional frequency band (0.010-0.080 Hz), slow-4 (0.027-0.073 Hz) band and slow-5 (0.010-0.027 Hz) band were conducted. Two-sample t test was used to compare the ReHo values between the two groups, and Pearson correlation analysis was used to explore the relationship between the ReHo values of PDM patients and clinical measures.Results Compared with HC (FEW corrected, voxel P<0.001, cluster P<0.05, two tailed), PDM patients showed increased ReHo values in the right parahippocampus gyrus, temporal pole superior temporal gyrus, basal nucleus and anterior cingutate, and decreased ReHo values in the left middle temporal gyrus, inferior temporal gyrus and insula both in conventional frequency band and slow-4 band, while PDM patients showed increased ReHo values in the right middle frontal gyrus and decreased ReHo values in the left cerebellum 8 region compared with HC in slow-5 band. Correlation analysis showed that COX1 was positively correlated with ReHo values in the left middle temporal gyrus in conventional frequency band in PDM patients.Conclusions The present study revealed frequency-specific ReHo alterations in PDM, among which, the changes in activity in brain regions associated with pain afference, emotion and memory found in the conventional band were roughly consistent with slow-4 band, while slow-5 band may provide additional findings, providing new insights into the neurobiological mechanisms of PDM.
[Keywords] primary dysmenorrhea;resting-state functional magnetic resonance imaging;regional homogeneity;frequency-specific;magnetic resonance imaging

LIU Ni1   ZHANG Ya'nan1   DAI Na1   HUO Jianwei1   ZHANG Lei1   HUANG Yiran2   LIU Junlian1*  

1 Department of Radiology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China

2 School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing 100029, China

Corresponding author: Liu JL, E-mail:

Conflicts of interest   None.

ACKNOWLEDGMENTS University-Level Longitudinal Research Development Foundation of Beijing University of Chinese Medicine (No. 2020-ZXFZJJ-035).
Received  2022-12-27
Accepted  2023-05-23
DOI: 10.12015/issn.1674-8034.2023.06.006
Cite this article as: LIU N, ZHANG Y N, DAI N, et al. Brain regional homogeneity alterations in multi-frequency bands in primary dysmenorrhea: A resting-state functional magnetic resonance imaging study[J]. Chin J Magn Reson Imaging, 2023, 14(6): 39-44. DOI:10.12015/issn.1674-8034.2023.06.006.

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