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Clinical Article
Research on the evaluation of the liver function grading for the patients with hepatitis B cirrhosis using T1 mapping based extracellular volume fraction
XU Hui  LI Yaguang  MU Jiankui  YAN Zijia  HAN Xiaonan  LEI Licun 

Cite this article as: XU H, LI Y G, MU J K, et al. Research on the evaluation of the liver function grading for the patients with hepatitis B cirrhosis using T1 mapping based extracellular volume fraction[J]. Chin J Magn Reson Imaging, 2023, 14(5): 132-138. DOI:10.12015/issn.1674-8034.2023.05.023.

[Abstract] Objective To evaluate the research value of the extracellular volume fraction (ECV) in evaluating the liver function grading [Child-Pugh grade and albumin-bilirubin (ALBI) grade] for the patients with chronic hepatitis B cirrhosis, and to explore the ECV value difference among various liver function grading groups.Materials and Methods The patients that all received the gadobenate dimeglumine (Gd-BOPTA) enhanced MRI examination in the First Hospital of Hebei Medical University from January to October 2022 were selected, which all included the laboratory test results within two weeks before or after the MRI examination. A total of 67 cases of patients were included, with 17 cases in normal liver function (NLF) group and 50 cases in the cirrhosis group. The T1 mapping including the plain scan and balance phases was performed on all of these patients, and the T1 values of the patients' liver parenchyma and abdominal aorta in the plain scan and balance phases were measured, based on which, in combination with the hematocrit levels, the ECV values were calculated. The patients of the cirrhosis group were divided into a Child-Pugh grade group and an ALBI grade group as per the two liver function grading methods. The Spearman correlation coefficient was used to analyze the correlation between the ECV values and the scores as a result of the liver function scoring models such as ALBI grade and Child-Pugh grade. The one-way analysis of variance was used to compare the differences of the ECV values among the groups. The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficacy of the ECV values in identifying the patients of the different liver function groups, and the cut-off values, sensitivity, specificity and area under the curve (AUC) were calculated.Results There was a significant positive correlation between the ECV values and the grades of the Child-Pugh grade (r=0.694, P<0.01) and those of the ALBI grade (r=0.689, P<0.01), and the ECV values increased with the increase of the liver function grading (Child-Pugh grade, and ALBI grade). There was a significant difference in the ECV values between the patients of the Child-Pugh grade group and those of the ALBI grade group (P<0.01). In the case of the Child-Pugh grade group, the AUCs of the ECV identification of NLF vs. CP-A, CP-A vs. CP-B and CP-B vs. CP-C were 0.82, 0.78 and 0.84, respectively. In the case of the ALBI grade group, the AUCs of the ECV identification of NLF vs. ALBI 1, ALBI 1 vs. ALBI 2 and ALBI 2 vs. ALBI 3 were 0.79, 0.70 and 0.91, respectively.Conclusions The ECV value based on the T1 mapping is a reliable index for evaluating the liver function of the patients with chronic hepatitis B cirrhosis. The diagnostic efficacy of the ALBI grading in evaluating the liver function of the patients with chronic hepatitis B cirrhosis is comparable to that of the Child-Pugh grading, but it is simpler and more objective, and therefore can be used as a complement to the Child-Pugh grading.
[Keywords] liver cirrhosis;liver function;albumin-bilirubin grade;Child-Pugh grade;T1 mapping;extracellular volume fraction;magnetic resonance imaging

XU Hui1   LI Yaguang1   MU Jiankui1   YAN Zijia1   HAN Xiaonan2   LEI Licun1*  

1 Departent of Radiology and Nuclear Medicine, the First Hospital of Hebei Medical University, Shijiazhuang 050031, China

2 Departent of Radiology, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China

Corresponding author: Lei LC, E-mail:

Conflicts of interest   None.

ACKNOWLEDGMENTS Hebei Province Medical Science Research Project (No. 20231013).
Received  2022-12-30
Accepted  2023-05-06
DOI: 10.12015/issn.1674-8034.2023.05.023
Cite this article as: XU H, LI Y G, MU J K, et al. Research on the evaluation of the liver function grading for the patients with hepatitis B cirrhosis using T1 mapping based extracellular volume fraction[J]. Chin J Magn Reson Imaging, 2023, 14(5): 132-138. DOI:10.12015/issn.1674-8034.2023.05.023.

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