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MRI advances of hippocampus in adolescents with depression
FENG Ruohan  ZHUO Lihua  LI Hongwei  OUYANG Xinqin  LONG Yongjun  HUANG Xiaoqi 

Cite this article as: FENG R H, ZHUO L H, LI H W, et al. MRI advances of hippocampus in adolescents with depression[J]. Chin J Magn Reson Imaging, 2023, 14(4): 120-125. DOI:10.12015/issn.1674-8034.2023.04.021.

[Abstract] Depression is the main cause of disability and death in adolescents. The pathogenesis of depression is still unclear. Researchers have suggested that the hippocampus plays a critical role in depression pathogenesis. Many neuroimaging studies related to depression have targeted the hippocampus in recent years,but few studies on adolescents have been conducted. The advanced MRI methods of hippocampus in adolescents with depression are reviewed in this article, such as structural and functional MRI, magnetic resonance spectroscopy, and findings of structure, function, and metabolism abnormalities associated with early adverse experiences and stressful events. This may be a neurobiological mechanism behind depression caused by these risk factors. More longitudinal and large-scale studies are needed to further verify these previous findings, and the relationship between risk factors such as the environment and brain changes needs to be further explored. This review summarized current status and shortcomings of research on the hippocampus of adolescents with depression in order to provide a reference direction for future research.
[Keywords] depression;adolescent;hippocampus;magnetic resonance imaging;structural magnetic resonance imaging;functional magnetic resonance imaging;magnetic resonance spectroscopy;diffusion tensor imaging

FENG Ruohan1, 2   ZHUO Lihua1   LI Hongwei1   OUYANG Xinqin1   LONG Yongjun1   HUANG Xiaoqi2, 3*  

1 Department of Radiology, the Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang 621000, China

2 Huaxi MR Research Center (HMRRC), West China Hospital, Sichuan University, Chengdu 610041, China

3 Functional and Molecular Imaging Key Laboratory of Sichuan Province, Chengdu 610041, China

Corresponding author: Huang XQ, E-mail:

Conflicts of interest   None.

ACKNOWLEDGMENTS Sichuan Provincial Youth Grant (No. 2017JQ0001); Project of Sichuan Applied Psychology Research Center (No. CSXL-203005, CSXL-203006).
Received  2022-10-28
Accepted  2023-03-09
DOI: 10.12015/issn.1674-8034.2023.04.021
Cite this article as: FENG R H, ZHUO L H, LI H W, et al. MRI advances of hippocampus in adolescents with depression[J]. Chin J Magn Reson Imaging, 2023, 14(4): 120-125. DOI:10.12015/issn.1674-8034.2023.04.021.

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