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Clinical Article
Value of edema on T2WI before treatment in predicting the efficacy of neoadjuvant chemotherapy for breast cancer
ZHU Yanfang  ZHU Yongqi  JI Hua  LÜ Jing  HE Ying  LIU Yun  ZHU Li 

Cite this article as: ZHU Y F, ZHU Y Q, JI H, et al. Value of edema on T2WI before treatment in predicting the efficacy of neoadjuvant chemotherapy for breast cancer[J]. Chin J Magn Reson Imaging, 2023, 14(4): 76-81, 88. DOI:10.12015/issn.1674-8034.2023.04.013.

[Abstract] Objective To explore the predictive value of breast edema on T2WI before neoadjuvant chemotherapy (NAC) and breast edema's influencing factors.Materials and Methods From October 2018 to March 2022, the data of patients with breast cancer diagnosed by immunohistochemical technique and treated with NAC in General Hospital of Ningxia Medical University were retrospectively collected. According to the breast edema score (BES) on T2WI before NAC, no edema, peritumoral edema, prechest edema, and subcutaneous edema were respectively defined as BES1, BES2, BES3, and BES4. Postoperative pathological complete response (pCR) was used as the evaluation standard for the efficacy of NAC. SPSS software was used for single factor analysis of BES and its clinicopathological characteristics to predict the efficacy. The correlation between BES and tumor diameter, Ki-67, histological grade, NAC schedule, molecular typing, axillary lymph node metastasis was further evaluated.Results A total of 260 subjects were included, and the pCR rate was 40.4% (105/260). Univariate analysis showed that there were significant differences in BES, tumor diameter, Ki-67, NAC schedule and molecular typing between the pCR group and the Non-pCR group (P<0.05). Analysis of the influencing factors of breast edema showed that BES was correlated with tumor diameter and axillary lymph node metastasis (P<0.05), and was positively correlated with tumor diameter (rs=0.442).Conclusions BES is helpful to predict the efficacy of NAC in breast cancer patients, and it is related to tumor diameter and axillary lymph node metastasis. Tumor diameter, Ki-67, NAC schedule and molecular typing were also effective predictors of NAC response.
[Keywords] breast cancer;neoadjuvant chemotherapy;T2 weighted imaging;breast edema;magnetic resonance imaging

ZHU Yanfang1   ZHU Yongqi2   JI Hua3   LÜ Jing1   HE Ying1   LIU Yun4*   ZHU Li4  

1 Clinical College, Ningxia Medical University, Yinchuan 750000, China

2 Department of Radiology, Ningxia Hui Autonomous Region People's Hospital, Yinchuan 750000, China

3 Department of Radiology, Lingwu People's Hospital of Ningxia, Lingwu 751400, China

4 Department of Radiology, General Hospital of Ningxia Medical University, Yinchuan 750000, China

Corresponding author: Liu Y, E-mail:

Conflicts of interest   None.

ACKNOWLEDGMENTS Ningxia Key Research and Development Project in 2022 (No. 2022BEG02025); Clinical Medicine First-Class Discipline Open Project of Clinical Medicine School of Ningxia Medical University in 2020.
Received  2022-11-19
Accepted  2023-04-11
DOI: 10.12015/issn.1674-8034.2023.04.013
Cite this article as: ZHU Y F, ZHU Y Q, JI H, et al. Value of edema on T2WI before treatment in predicting the efficacy of neoadjuvant chemotherapy for breast cancer[J]. Chin J Magn Reson Imaging, 2023, 14(4): 76-81, 88. DOI:10.12015/issn.1674-8034.2023.04.013.

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