Share this content in WeChat
Clinical Article
The diagnostic value of 3.0 T DCE-MRI combined with DWI in differentiating pleomorphic adenoma and basal cell adenoma of salivary gland
LI Sen  SHAO Shuo  YAN Xiaofan  WU Jianwei  ZHAO Xiaomeng  ZHENG Ning 

Cite this article as: LI S, SHAO S, YAN X F, et al. The diagnostic value of 3.0 T DCE-MRI combined with DWI in differentiating pleomorphic adenoma and basal cell adenoma of salivary gland[J]. Chin J Magn Reson Imaging, 2023, 14(4): 34-40. DOI:10.12015/issn.1674-8034.2023.04.007.

[Abstract] Objective To investigate the value of dynamic contrast-enhanced MRI (DCE-MRI) combined with diffusion-weighted imaging (DWI) in the differential diagnosis of salivary gland pleomorphic adenoma (PA) and basal cell adenoma (BCA).Materials and Methods Retrospective analysis of 55 cases with salivary gland tumors confirmed by pathology in Jining First People 's Hospital from December 2018 to August 2022, including 38 cases of PA and 17 cases of BCA. MRI data of all patients were collected and analyzed from picture archiving and communication system. The PA and BCA were compared and analyzed in time intensity curve (TIC) types, quantitative parameters [volume transfer constant (Ktrans), the rate constant (Kep), fractional volume of the extravascular-extracellular space (Ve), plasma fraction (Vp)] and apparent diffusion coefficient (ADC) value. Rreceiver operating characteristic (ROC) curve was used to evaluate the efficiency of DCE-MRI combined with DWI in distinguishing PA and BCA.Results The mean ADC value of PA [(1.74±0.36)×10-3 mm2/s] was higher than that of BCA [(1.32±0.13)×10-3 mm2/s], and the difference was statistically significant (P<0.05). There were 5 cases of type B and 11 cases of type C in TIC of 17 cases of BCA, and 27 cases of type A, 10 cases of type C in 38 cases of PA. The Kep value of PA was lower than that of BCA and the Ve value of PA was higher than that of BCA (P<0.05 ) in the quantitative parameters of DCE-MRI. There was no significant difference in Ktrans and Vp values between PA and BCA groups. The area under the curve (AUC) of ADC, TIC, Kep and Ve were 0.875, 0.808, 0.822 and 0.747, respectively. And the AUC of multi-parameter combination was 0.895-0.952.Conclusions TIC, Kep, Ve and ADC are all helpful to differentiate BCA and PA in salivary gland, and the combination of multiple parameters further improves its diagnostic efficiency.
[Keywords] salivary gland tumors;pleomorphic adenoma;basal cell adenoma;dynamic contrast-enhanced;magnetic resonance imagining;diffusion weighted imaging;quantitative parameter

LI Sen1   SHAO Shuo2   YAN Xiaofan1   WU Jianwei3   ZHAO Xiaomeng3   ZHENG Ning2*  

1 Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan 250000, China

2 Department of Radiology, Jining First People's Hospital, Jining 272000, China

3 Clinical Medical College, Jining Medical College, Jining 272013, China

Corresponding author: Zheng N, E-mail:

Conflicts of interest   None.

ACKNOWLEDGMENTS Key Research and Development Program of Jining (No. 2021YXNS022).
Received  2022-11-25
Accepted  2023-04-11
DOI: 10.12015/issn.1674-8034.2023.04.007
Cite this article as: LI S, SHAO S, YAN X F, et al. The diagnostic value of 3.0 T DCE-MRI combined with DWI in differentiating pleomorphic adenoma and basal cell adenoma of salivary gland[J]. Chin J Magn Reson Imaging, 2023, 14(4): 34-40. DOI:10.12015/issn.1674-8034.2023.04.007.

ALMESLET A S. Pleomorphic adenoma: a systematic review[J]. Int J Clin Pediatr Dent, 2020, 13(3): 284-287. DOI: 10.5005/jp-journals-10005-1776.
WANG H B, HUAN T, HAN Z J, et al. Analysis of correlation between conventional MR signs and pathology of parotid pleomorphic adenoma[J]. J China Clin Med Imaging, 2020, 31(11): 783-787. DOI: 10.12117/jccmi.2020.11.006.
NAGAO K, MATSUZAKI O, SAIGA H, et al. Histopathologic studies of basal cell adenoma of the parotid gland[J]. Cancer, 1982, 50(4): 736-745. DOI: 10.1002/1097-0142(19820815)50:4<736::aid-cncr2820500419>;2-m.
RAJASENTHIL V, RAVI A. Basal cell adenoma of the parotid gland-A rare entity[J]. Indian J Surg, 2014, 76(5): 408-410. DOI: 10.1007/s12262-013-1010-5.
ROBINSON R A. Basal Cell Adenoma and Basal Cell Adenocarcinoma[J]. Surg Pathol Clin, 2021, 14(1): 25-42. DOI: 10.1016/j.path.2020.09.005.
WITT R L, NICOLAI P. Recurrent benign salivary gland neoplasms[J]. Adv Otorhinolaryngol, 2016, 78: 63-70. DOI: 10.1159/000442126.1.
PSYCHOGIOS G, BOHR C, CONSTANTINIDIS J, et al. Review of surgical techniques and guide for decision making in the treatment of benign parotid tumors[J]. Eur Arch Otorhinolaryngol, 2021, 278(1): 15-29. DOI: 10.1007/s00405-020-06250-x.
MATSUSUE E, FUJIHARA Y, MATSUDA E, et al. Vanishing Parotid Tumors on MR Imaging[J]. Yonago Acta Med, 2018, 61(1): 33-39. DOI: 10.33160/yam.2018.03.005.
STANEK J J, KHARIWALA S S. What Is the Utility of Fine-Needle Aspiration in Parotid Gland Neoplasms?[J]. Laryngoscope, 2019, 129(6): 1255-1256. DOI: 10.1002/lary.27549.
LARIAN B. Parotidectomy for Benign Parotid Tumors[J]. Otolaryngol Clin North Am, 2016, 49(2): 395-413. DOI: 10.1016/j.otc.2015.10.006.
DIJKHOFF R A P, BEETS-TAN R G H, LAMBREGTS D M J, et al. Value of DCE-MRI for staging and response evaluation in rectal cancer: A systematic review[J]. Eur J Radiol, 2017, 95: 155-168. DOI: 10.1016/j.ejrad.2017.08.009.
KITAMOTO E, CHIKUI T, KAWANO S, et al. The application of dynamic contrast-enhanced MRI and diffusion-weighted MRI in patients with maxillofacial tumors[J]. Acad Radiol. 2015, 22(2): 210-216. DOI: 10.1016/j.acra.2014.08.016.
ABDEL RAZEK A A, SAMIR S, ASHMALLA G A. Characterization of Parotid Tumors With Dynamic Susceptibility Contrast Perfusion-Weighted Magnetic Resonance Imaging and Diffusion-Weighted MR Imaging[J]. J Comput Assist Tomogr, 2017, 41(1): 131-136. DOI: 10.1097/RCT.0000000000000486.
YABUUCHL H, FUKUYA T, TAJIMA T, et a1. Salivary 91 and tumors: diagnostic value of gadoIinium-enhanced dynamic MR imaging with histopathologic correlation[J]. Radiology, 2003, 226(2): 345-354. DOI: 10.1148/radiol.2262011486.
YAN X F, SHAO S, ZHENG N, et al. Differentiating salivary gland pleomorphic adenoma from basal cell adenoma basedon multimodal magnetic resonance imaging radiomics[J]. Chin J Magn Reson Imaging, 2022, 13(7): 22-28. DOI: 10.12015/issn.1674-8034.2022.07.005.
LIU H X, DUAN J F, MA Y M, et al. Clinical and CT characteristics of basal cell adenoma in parotid gland[J]. J Pract Radiol, 2019, 35(6): 876-879. DOI: 10.3969/j.issn.1002G1671.2019.06.006.
LIAO J Y, DU J B, LIU Y X, et al. The diagnostic value of dual-phase CT enhancement appearances of basal cell adenoma and pleomorphic adenoma in the parotid gland[J]. Med J Chin Peop Arm Pol For, 2020, 31(5): 382-385. DOI: 10.3969/j.issn.1004-3594.2020.05.004.
KARAMAN C Z, TANYERI A, ÖZGÜR R, ÖZTÜRK V S. Parotid gland tumors: comparison of conventional and diffusion-weighted MRI findings with histopathological results[J/OL]. Dentomaxillofac Radiol, 2021, 50(4): 20200391 [2022-11-05]. DOI: 10.1259/dmfr.20200391.
MARAGHELLI D, PIETRAGALLA M, CORDOPATRI C, et al. Magnetic resonance imaging of salivary gland tumours: Key findings for imaging characterization[J/OL]. Eur J Radiol, 2021, 139: 109716 [2022-11-05]. DOI: 10.1016/j.ejrad.2021.109716.
HUAN T, WANG H B, HAN Z J, et al. MRI diagnostic value and pathological correlation analysis of pleomorphic adenoma and basal cell adenoma ≤ 2 cm in diameter[J]. J Pract Radiol, 2020, 36(11): 1727-1731. DOI: 10.3969/j.issn.1002-1671.2020.11.006.
MURAYAMA Y, KAMITANI T, SAGIYAMA K, et al. Evaluation of MR imaging findings differentiating parotid basal cell adenomas from other parotid tumors[J/OL]. Eur J Radiol, 2021, 144: 109980 [2022-11-05]. DOI: 10.1016/j.ejrad.2021.109980.
JIANG J S, ZHU L N, CHEN W, et al. Added value of susceptibility-weighted imaging to diffusion-weighted imaging in the characterization of parotid gland tumors[J]. Eur Arch Otorhinolaryngol, 2020, 277(10): 2839-2846. DOI: 10.1007/s00405-020-05985-x.
CHEN P, DONG B, ZHANG C, et al. The histogram analysis of apparent diffusion coefficient in differential diagnosis of parotid tumor[J/OL]. Dentomaxillofac Radiol, 2020, 49(5): 20190420 [2022-11-05]. DOI: 10.1259/dmfr.20190420.
CHENG J F, ZHENG N, SHAO S, et al. Diagnostic value of 3.0 T multiparametric MRI for discriminating parotid basal cell adenoma from pleomorphic adenoma[J]. J Pract Radiol, 2020, 36(4): 550-553. DOI: 10.3969/j.issn.1002-1671.2020.04.01.
HUANG N, CHEN Y, SHE D, et al. Diffusion kurtosis imaging and dynamic contrast-enhanced MRI for the differentiation of parotid gland tumors[J]. Eur Radiol, 2022, 32(4): 2748-2759. DOI: 10.1007/s00330-021-08312-y.
ANG T, JUNIAT V, PATEL S, et al. Evaluation of orbital lesions with DCE-MRI: a literature review[J]. Orbit, 2022: 1-9. DOI: 10.1080/01676830.2022.2149819.
LIN M X, YUN H, LU Y F, et al. Differential diagnosis of different type of tumors in the parotid gland by 3.0 T magnetic resonance dynamic enhanced imaging and diffusion -weighted imaging[J]. Chin J Exp Surg, 2019, 36(4): 765-767. DOI: 10.3760/cma.j.issn.1001-9030.2019.04.053.
SOURBRON S P, BUCKLEY D L. On the scope and interpretation of the Tofts models for DCE-MRI[J]. Magn Reson Med, 2011, 66(3): 735-745. DOI: 10.1002/mrm.22861.
MARKIET K, GLINSKA A, NOWICKI T, et al. Feasibility of Intravoxel Incoherent Motion (IVIM) and Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) in Differentiation of Benign Parotid Gland Tumors[J/OL]. Biology (Basel), 2022, 11(3): 399 [2022-11-05]. DOI: 10.3390/biology11030399.
LEE D K, CHUNG K W, BAEK C H, et al. Basal cell adenoma of the parotid gland: characteristics of 2-phase helical computed tomography and magnetic resonance imaging[J]. J Comput Assist Tomogr, 2005, 29(6): 884-888. DOI: 10.1097/01.rct.0000183273.70422.c4.
WU T T, BAO Y Y, ZHOU S H, et al. Basal cell adenoma in the parapharyngeal space resected via trans-oral approach aided by endoscopy: Case series and a review of the literature[J/OL]. Medicine (Baltimore), 2018, 97(34): e11837 [2022-11-05]. DOI: 10.1097/MD.0000000000011837.
TOFTS P S, BRIX G, BUCKLEY D L, et al. Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols[J]. J Magn Reson Imaging, 1999, 10(3): 223-232. DOI: 10.1002/(sici)1522-2586(199909)10:3<223::aid-jmri2>;2-s.
WANG Y, SONG L, GUO J, et al. Value of quantitative multiparametric MRI in differentiating pleomorphic adenomas from malignant epithelial tumors in lacrimal gland[J]. Neuroradiology, 2020, 62(9): 1141-1147. DOI: 10.1007/s00234-020-02455-3.
LI Y, MA L, CHENG L Q, et al. Basal Cell Adenomas of the Parotid Gland: CT and MRI Features[J]. Chin J Med Imaging, 2012, 20(4): 252-254. DOI: 10.3969/j.issn.1005-5185.2012.04.004.
XU Z, ZHENG S, PAN A, et al. A multiparametric analysis based on DCE-MRI to improve the accuracy of parotid tumor discrimination[J]. Eur J Nucl Med Mol Imaging, 2019, 46(11): 2228-2234. DOI: 10.1007/s00259-019-04447-9.
XU Z, CHEN M, ZHENG S, et al. Differential diagnosis of parotid gland tumours: Application of SWI combined with DWI and DCE-MRI[J/OL]. Eur J Radiol, 2022, 146: 110094 [2022-11-05]. DOI: 10.1016/j.ejrad.2021.110094.
YABUUCHI H, KAMITANI T, SAGIYAMA K, et al. Characterization of parotid gland tumors: added value of permeability MR imaging to DWI and DCE-MRI[J]. Eur Radiol, 2020, 30(12): 6402-6412. DOI: 10.1007/s00330-020-07004-3.

PREV Clinical value of high-resolution compressed sensing TOF-MRA in assessing Suzuki classification and the dilatation of hemorrhage related vascular in patients with moyamoya disease
NEXT Clinical application of DWI combined with DKI and SWI in the diagnosis of parotid tumors

Tel & Fax: +8610-67113815    E-mail: