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Research progress of amide proton transfer imaging in rectal neoplasms
MA Wenting  WANG Lili  WEI Zhaokun  LEI Jiankai  MA Xiaomei 

Cite this article as: MA W T, WANG L L, WEI Z K, et al. Research progress of amide proton transfer imaging in rectal neoplasms[J]. Chin J Magn Reson Imaging, 2023, 14(3): 189-192, 197. DOI:10.12015/issn.1674-8034.2023.03.035.

[Abstract] Amide proton transfer (APT) imaging is based on the exchange of amide protons in intracellular proteins and polypeptides with hydrogen protons in free water. The more malignant rectal neoplasms, the more intracellular free proteins and polypeptides, and the higher APT signal. We summarizes the relevant domestic and foreign literatures of APT imaging in the diagnosis of rectal neoplasms, hoping to use APT imaging in the clinical early diagnosis and curative effect evaluation, improving the survival rate of rectal neoplasms patients. Domestic and foreign literature studies about APT imaging diagnosis of rectal neoplasms mainly focus on the following aspects: evaluating the histological grade of rectal cancer, predicting the efficacy of chemotherapy, predicting whether the Kirsten rat sarcoma (KRAS) gene is mutated, and predicting the invasion of rectal neoplasms. Compared with conventional MRI sequence, APT imaging can non-invasively predict the invasion of rectal neoplasms and observe the molecular biological changes. At present, APT imaging is most commonly used in brain tumors, the components of cavity organs are complex, the clinical application is limited, so our article summarizes the relevant literature, explores the method of uniform magnetic field, apply APT imaging which a molecular biological examination method to diagnose rectal cancer, and opening a new field about clinical application of APT imaging.
[Keywords] rectal neoplasms;amide proton transfer imaging;chemical exchange saturation transfer;magnetic resonance imaging;diagnosis;grading;prediction

MA Wenting1   WANG Lili1*   WEI Zhaokun1   LEI Jiankai2   MA Xiaomei1  

1 Department of Radiology, Gansu Provincial Hospital, Lanzhou 730000, China

2 Department of Radiology, Gaotai Hospital of Traditional Chinese Medicine, Zhangye 734300, China

Corresponding author: Wang LL, E-mail:

Conflicts of interest   None.

ACKNOWLEDGMENTS Gansu Province Youth Fund Project (No. 20JR5RA143); Scientific Research Fund in Gansu Provincial People's Hospital (No. 20GSSY4-45).
Received  2022-10-23
Accepted  2023-02-28
DOI: 10.12015/issn.1674-8034.2023.03.035
Cite this article as: MA W T, WANG L L, WEI Z K, et al. Research progress of amide proton transfer imaging in rectal neoplasms[J]. Chin J Magn Reson Imaging, 2023, 14(3): 189-192, 197. DOI:10.12015/issn.1674-8034.2023.03.035.

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