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Clinical Article
Study on the value of mDixon-Quant technique in the diagnosis and prognosis evaluation of invasive ductal breast cancer
WANG Zhuo  WU Qi  NING Ning  LIANG Hongbing  TIAN Jiahe  ZHANG Lina  SONG Qingwei 

Cite this article as: WANG Z, WU Q, NING N, et al. Study on the value of mDixon-Quant technique in the diagnosis and prognosis evaluation of invasive ductal breast cancer[J]. Chin J Magn Reson Imaging, 2023, 14(3): 65-71. DOI:10.12015/issn.1674-8034.2023.03.012.

[Abstract] Objective To explore the correlation of FF and T2* values derived from mDixon-Quant imaging with pathological histological grade and prognostic factors of invasive breast carcinoma of the breast.Materials and Methods A total of 88 cases of invasive ductal carcinoma of the breast confirmed by pathology were retrospective analyzed (57 low-grade cases and 31 high-grade cases). The mDixon-Quant scanning was performed before operation, the FF, T2* values and basic clinical information including with age, menopausal status, tumor size, tumor type, body mass index (BMI), amount of fibroglandular tissue (FGT) and background parenchymal enhancement (BPE) between the two groups. The FF and T2* values were compared with some prognostic pathological features such as histological grade, estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER-2), Ki-67 and molecular typing of breast cancer. The Mann-Whitney U test or t test was used for continuous variables; R×C χ2 test was used for categorical variables; Spearman rank correlation test was used for correlation test. The Receiving operator characteristic (ROC) curve was plotted and the area under curve (AUC) was calculated to compare the diagnostic performance.Results Finally, 88 lesions of 88 patients with invasive ductal carcinoma of the breast (mean age 48.93±9.49, range 31-68 years) were included, and FF and T2* values were measured with good inter- and intra-observer agreement with intra-class correlation coefficients (ICC) of 0.964 and 0.909, respectively. The study found that there was no statistical significance between the two groups in age, menopause situation, tumor size, maximum diameter of the lesion, tumor type, FGT, and BPE of breast parenchyma. Both FF and T2* values were statistically significant between the two groups of different histological grades (P<0.001). Compared with the low-grade group, the high-grade group had a smaller FF value (5.06%±2.56% vs. 8.33%±3.92%). FF value was negatively correlated with histological grade (r=-0.406, P<0.001).The T2* value of the high-grade group was higher than that of the low-grade group [(29.94±8.55) ms vs. (22.85±5.39) ms]. T2* value was positively correlated with histological grade (r=0.397, P<0.001). The AUC was 0.738 and 0.748 for FF value and T2* value to predict histological grade, respectively. The combined diagnostic AUC of FF and T2* values was 0.797, but there was no statistically significant difference with the diagnostic performance of a single parameter. There was a statistically significant difference in FF values in the distribution between different ER and molecular typing groups (P=0.038 and 0.005). FF values were positively correlated with ER (P=0.037) but not with PR, Ki-67, HER-2 and molecular typing (all P>0.05). T2* values were statistically significantly different between ER, PR, Ki-67 and molecular typing groups (all P<0.05). In addition, it was negatively correlated with ER and PR (P<0.001 and P=0.003), and positively correlated with Ki-67 and molecular typing (all P<0.001).Conclusions FF and T2* values derived from mDixon-Quant were independent predictors of histological grade of invasive ductal carcinoma of the breast, and the combination of the two parameter values helped to improve the specificity of the diagnosis and correlated with prognostic pathological features.
[Keywords] breast cancer;invasive ductal carcinoma;histological grade;molecular typing;fat quantification;mDixon-Quant;magnetic resonance imaging

WANG Zhuo1   WU Qi1   NING Ning1   LIANG Hongbing1   TIAN Jiahe2   ZHANG Lina1*   SONG Qingwei1  

1 Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

2 Zhongshan College of Dalian Medical University, Dalian 116085, China

Corresponding author: Zhang LN, E-mail:

Conflicts of interest   None.

ACKNOWLEDGMENTS 2022 Liaoning Adult Education Association Continuing Education Teaching Reform Research Project (No. LCYJGZXYB22100); 2022 General Project of "Peak Climbing Plan" of Dalian City Key Specialty of Medicine (No. 2022DF042); 2021 Dalian Medical University Teaching Reform Research General Project (No. DYLX21036).
Received  2022-10-18
Accepted  2023-02-28
DOI: 10.12015/issn.1674-8034.2023.03.012
Cite this article as: WANG Z, WU Q, NING N, et al. Study on the value of mDixon-Quant technique in the diagnosis and prognosis evaluation of invasive ductal breast cancer[J]. Chin J Magn Reson Imaging, 2023, 14(3): 65-71. DOI:10.12015/issn.1674-8034.2023.03.012.

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