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Clinical Article
Application value of arterial spin labeling imaging with dual parameters in evaluating collateral circulation and prognosis of acute ischemic stroke
JIANG Hailong  SU Wen  CHEN Huiyou  CHEN Yuchen  CHEN Guozhong  YIN Xindao 

Cite this article as: JIANG H L, SU W, CHEN H Y, et al. Application value of arterial spin labeling imaging with dual parameters in evaluating collateral circulation and prognosis of acute ischemic stroke[J]. Chin J Magn Reson Imaging, 2023, 14(3): 53-57, 80. DOI:10.12015/issn.1674-8034.2023.03.010.

[Abstract] Objective To explore the value of arterial spin labeling (ASL) imaging with dual parameters in evaluating the collateral circulation and prognosis for patients with acute ischemic stroke (AIS).Materials and Methods From June 2022 to July 2022, multi-modal MRI and digital subtraction angiography (DSA) data of 35 AIS patients from Nanjing First Hospital were retrospectively analyzed. All patients were divided into three groups: high perfusion at early stage group (G1, n=21), high perfusion at later stage group (G2, n=8) and no- high perfusion group (G3, n=6) based on the ASL [inversion time (TI)=1500 ms, 2510 ms] imaging features of the infarct lesions. Collateral circulation was divided into good collateral circulation (grade 3-4) and poor collateral circulation (grade 0-2) according to the American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology (ASITN/SIR). The prognosis was divided into good outcome (≤2 points) and poor outcome (>2 points) according to modified Rankin Scale (mRS) at 3-month follow-up. The differences of collateral circulation and prognosis among three groups were analyzed using statistical methods.Results Compared with G3, G1 and G2 had lower National Institutes of Health Stroke Scale (NIHSS) score, better collateral circulation and good outcome. There was no significant difference in the collateral circulation between G1 and G2 (100.00% vs. 83.33%; P=0.180), while the rate of good outcome in G1 was significantly higher than that in G2 (100.00% vs. 50.00%; P=0.013). Spearman correlation analysis showed that G1, G2, G3 were positively correlated with collateral circulation grade (r=0.720; P<0.001), and negatively correlated with prognosis mRS score (r=-0.843; P<0.001).Conclusions ASL imaging with double inversion time could effectively evaluate the collateral circulation and prognosis of AIS patients, and provide vital evidence for therapeutic decision-making.
[Keywords] acute ischemic stroke;dual parameters;arterial spin labeling;magnetic resonance imaging;collateral circulation;prognosis

JIANG Hailong   SU Wen   CHEN Huiyou   CHEN Yuchen   CHEN Guozhong   YIN Xindao*  

Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China

Corresponding author: Yin XD, E-mail:

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 82001811); Natural Science Foundation of Jiangsu Province (No. BK20201118).
Received  2022-11-14
Accepted  2023-03-06
DOI: 10.12015/issn.1674-8034.2023.03.010
Cite this article as: JIANG H L, SU W, CHEN H Y, et al. Application value of arterial spin labeling imaging with dual parameters in evaluating collateral circulation and prognosis of acute ischemic stroke[J]. Chin J Magn Reson Imaging, 2023, 14(3): 53-57, 80. DOI:10.12015/issn.1674-8034.2023.03.010.

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