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A comparative study of three scanning sequences on the arterial phase and image quality of gadoxetic acid disodium liver-enhanced MRI
MA Feng  LIU Fen  ZHANG Shutong 

Cite this article as: MA F, LIU F, ZHANG S T. A comparative study of three scanning sequences on the arterial phase and image quality of gadoxetic acid disodium liver-enhanced MRI[J]. Chin J Magn Reson Imaging, 2023, 14(2): 125-131. DOI:10.12015/issn.1674-8034.2023.02.021.

[Abstract] Objective To investigate the effects of shortened acquisition time and multiple arterial phase scanning techniques on gadoxetate acid disodium liver-enhanced MRI arterial phase imaging.Materials and Methods Retrospective analysis of 253 patients who underwent liver-enhanced MRI with gadoxetate acid disodium from May 2018 to December 2021 was performed. Patients were divided into three groups according to different examination modalities: conventional volumetric interpolated breath-hold examination (C-VIBE) in 87 cases (single-artery phase, scan time 16 s); shortened acquisition volumetric interpolated breath-hold examination (S-VIBE) in 78 cases (single-artery phase, scan time 12 s); multi-arterial phase scans (CAIPIRINHA-Dixon-TWIST-VIBE, CDT-VIBE) of 88 cases (five multi-arterial phases, scan time 16 s). We evaluated the phase and image quality of the arterial phases of the images in the three groups separately, all using the quadratic method. The image phase was divided according to the degree of hepatic artery and portal vein display; the subjective image quality was evaluated in terms of image artifacts, liver margin definition and lesion display, and the objective image quality included signal to noise ratio (SNR) and contrast to noise ratio (CNR). Categorical variables were expressed as number of cases and percentages. χ2 test was used to deal with categorical variables. Measures are expressed as mean±standard deviation (x¯±s), and one-way ANOVA was used to compare the differences in age between groups; the non-parametric Kruskal-Wallis test was used to compare the differences in image quality between the three serial groups and within the multi-arterial phase group and the differences in SNR and CNR of the three serial images.Results The differences in clinical characteristics (gender, age, pleural fluid, ascites, chronic obstructive disease, cirrhosis) between the three groups were not statistically significant (P>0.05). There was good agreement between the two MRI physicians in the assessment of arterial phase and image quality (Kappa value>0.7). In the arterial phase images, the best images in the CDT-VIBE group were scored better than in the C-VIBE and S-VIBE groups (H=23.698, P<0.001). In the early arterial images, the best image score was better in the CDT-VIBE group than in the C-VIBE group (H=19.415, P=0.043). The best images in the CDT-VIBE group were much better in the early and late arterial phases than in the C-VIBE and S-VIBE groups (P<0.05). The early arterial images in the CDT-VIBE group were better in the first and second phases than in the last three phases (P<0.05); the rate of excellent images in the fourth phase of the late arterial phase (78.4%) was much higher than that in the first three phases (P<0.05). The SNR (H=3.854, P=0.146) and CNR (H=2.120, P=0.346) of the three groups of images were not statistically significant.Conclusions After gadoxetate acid disodium injection, the S-VIBE sequence with shortened acquisition time cannot effectively reduce the images of breath-holding failure, while the CDT-VIBE sequence with multi-arterial phase acquisition can provide more excellent arterial phase images, which can provide both early arterial phase images depicting vessels and late arterial phase images with lesion enhancement information, and can be promoted in clinical applications.
[Keywords] liver;hepatocellular carcinoma;magnetic resonance imaging;gadoxetate acid disodium;arterial phase;image quality

MA Feng   LIU Fen   ZHANG Shutong*  

Department of Radiology, Wuhan Central Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China

*Correspondence to: Zhang ST, E-mail:

Conflicts of interest   None.

Received  2022-09-23
Accepted  2023-01-12
DOI: 10.12015/issn.1674-8034.2023.02.021
Cite this article as: MA F, LIU F, ZHANG S T. A comparative study of three scanning sequences on the arterial phase and image quality of gadoxetic acid disodium liver-enhanced MRI[J]. Chin J Magn Reson Imaging, 2023, 14(2): 125-131. DOI:10.12015/issn.1674-8034.2023.02.021.

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