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Clinical Article
The diagnostic value of T1 mapping and APTw imaging in chronic kidney disease
WANG Yue  JU Ye  BU Xinmiao  CHEN Lihua  WANG Nan  LIU Ailian 

Cite this article as: WANG Y, JU Y, BU X M, et al. The diagnostic value of T1 mapping and APTw imaging in chronic kidney disease[J]. Chin J Magn Reson Imaging, 2023, 14(2): 56-60, 67. DOI:10.12015/issn.1674-8034.2023.02.010.

[Abstract] Objective To explore the value of T1 mapping and amide proton transfer weighted (APTw) imaging in differentiating chronic kidney disease (CKD) patients from healthy people.Materials and Methods A total of 21 cases of patients (6 females, 15 males) with CKD who underwent 3.0 T MRI from August 2019 to October 2020 were retrospectively collected. All patients were diagnosed according to the clinical practice guidelines of CKD in the department of nephrology of the First Affiliated Hospital of Dalian Medical University. At the same time, the data of 24 healthy volunteers were collected as the control group. All raw images were imported into the ISP workstation to generate pseudo-color images. Regions of interest (ROIs) of 10-20 mm2 were placed in the cortex and medulla, respectively. The ROIs were selected from the upper, middle and lower pole of the kidney by two radiologists in a double-blind method, avoiding the renal sinus, large blood vessels and perirenal tissues. The T1 values and APT values of the cortex and medulla were statistically analyzed by SPSS 26.0 software. Intra-class correlation coefficients (ICC) were used to test the consistency of the measurement results between observers. Independent sample t test or Mann-Whitney U test was used to analyze the difference of parameter values between the two groups according to the normal distribution of data, and P<0.05 was considered statistically significant. Receiver operating characteristic (ROC) curve was used to analyze the diagnostic efficacy of each parameter. The corresponding threshold, sensitivity and specificity were obtained according to the maximum Youden index, and the area under the curve (AUC) was calculated.Results The inter-observer agreement was good (ICC>0.75). The renal cortical T1 value and cortical APT value in CKD group were significantly higher than those in healthy control group (P<0.05). The AUC value of T1 value of left renal cortex in differentiating CKD was 0.887, the sensitivity was 66.7%, and the specificity was 100.0%. The AUC value of APT value of left renal cortex in identifying CKD was 0.966, with a sensitivity of 95.2% and a specificity of 95.8%. The AUC value of T1 value of right renal cortex in differentiating CKD was 0.960, the sensitivity was 76.2%, and the specificity was 100.0%. The APT value of right renal cortex had a AUC value of 0.921, a sensitivity of 85.7%, and a specificity of 91.7% for identifying CKD.Conclusions T1 mapping and APTw imaging can noninvasiously and effectively identify CKD. The quantitative parameters based on T1 mapping and APTw imaging can reflect the structural and functional changes of the left and right kidneys to a certain extent, which is expected to provide certain reference value for clinical disease diagnosis.
[Keywords] chronic kidney disease;T1 mapping;amide proton transfer imaging;functional magnetic resonance imaging;differential diagnosis

WANG Yue1   JU Ye1   BU Xinmiao1   CHEN Lihua1   WANG Nan1   LIU Ailian1, 2*  

1 Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

2 Dalian Medical Imaging Artificial Intelligence Engineering Technology Research Center, Dalian 116011, China

*Correspondence to: Liu AL, E-mail:

Conflicts of interest   None.

Received  2022-08-02
Accepted  2023-01-12
DOI: 10.12015/issn.1674-8034.2023.02.010
Cite this article as: WANG Y, JU Y, BU X M, et al. The diagnostic value of T1 mapping and APTw imaging in chronic kidney disease[J]. Chin J Magn Reson Imaging, 2023, 14(2): 56-60, 67. DOI:10.12015/issn.1674-8034.2023.02.010.

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