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Technical Article
Feasibility study of fast arterial spin labeling imaging in brain on 3.0 T MRI scanner
YANG Yonggui  CHEN Fang  WU Xiufen  LIN Huifang  YAN Gen 

Cite this article as: YANG Y G, CHEN F, WU X F, et al. Feasibility study of fast arterial spin labeling imaging in brain on 3.0 T MRI scanner[J]. Chin J Magn Reson Imaging, 2023, 14(1): 116-123. DOI:10.12015/issn.1674-8034.2023.01.021.


[Abstract] Objective To explore the feasibility of Fast Arterial Spin Labeling (Fast ASL) imaging in brain on 3.0 T MRI scanner.Materials and Methods From December 2021 to August 2022, we adopted two grouping methods which are comparative grouping analysis and random grouping analysis, were used for grouping the subjects, data collection and perform prospective analysis in our hospital. The 3.0 T clinical research type MRI scanner and 16 channel head phased array coil were used to conduct fast ASL/ASL imaging of subjects and data acquisition of routine magnetic resonance sequences [T1WI, T2WI, T2 fat saturation and fluid attenuated inversion recovery (T2 fs FLAIR)], function and blood supply sequences [diffusion weighted imaging (DWI), perfusion weighted imaging (PWI), magnetic resonance angiography (MRA)]. Comparative grouping analysis group: the 25 subjects in comparative grouping analysis group were collected with two acquisition schemes (fast ASL and ASL) and analyzed with post-processing reconstruction. A total of 200 subjects in randomized grouping analysis group were randomly divided into 100 cases in turn according to the time sequence of examination, and image acquisition with single acquisition scheme (fast ASL or ASL) and analyzed with post-processing reconstruction. The 3D ASL of functool software package was used for post-processing on the GE AW 4.6 post-processing workstation, and the CBF image was scored and result evaluated for image quality. The statistical analysis was carried out using SPSS 26.0.Results In the comparative grouping analysis group, the CBF image quality scores of Fast ASL group and ASL group were (4.32±0.55) and (4.72±0.54) respectively. The paired data of the two groups were correlated, and the paired sample t-test showed that the difference was statistically significant (P<0.001). The CBF results of the two groups were correlated with the corresponding PWI results (P<0.001), and the differences were not statistically significant (P=1.00, 0.57). In the Fast ASL group, there were 8 cases without abnormal perfusion, 17 cases with abnormal perfusion, and the sensitivity and specificity of reflecting perfusion were 88.2% and 75.0% respectively. In the ASL group, there were 7 cases (94.1%) and 18 cases (75.0%), respectively. There was no significant difference between the two groups (P=0.84). In the randomized grouping analysis group, the CBF image quality scores of Fast ASL group and ASL group were (4.30±0.50) and (4.75±0.46) respectively. The variance of the two groups of data was not uniform (P=0.04), and the independent sample t-test showed that the difference was statistically significant (P<0.001). The CBF results of the two groups were correlated with the corresponding PWI results (P<0.001), and the differences were not statistically significant (P=0.44,0.21). In the Fast ASL group, there were 34 cases without abnormal perfusion, 66 cases with abnormal perfusion, and the sensitivity and specificity of reflecting perfusion were 90.5% and 75.7% respectively, while in the ASL group, there were 91.4% and 84.2%. There was no significant difference between the two groups (P=0.48). No matter which grouping method, the image quality score of CBF in the Fast ASL group was slightly lower than that in the ASL group, and the sensitivity and specificity of reflecting the perfusion situation were also slightly different, but the abnormal perfusion focus could be displayed and differentiated.Conclusions After optimizing the parameters, Fast ASL imaging can obtain a semi quantitative CBF map of the brain, which can clearly distinguish the normal and abnormal brain perfusion areas, provide accurate brain perfusion information for clinical diagnosis and treatment, and is of great significance for disease prevention and treatment. In particular, the acquisition time can be shortened by half. For subjects who cannot tolerate it, Fast ASL can obtain relatively satisfactory CBF effect, which is feasible.
[Keywords] cerebral infarction;brain tumor;cerebral blood flow;perfusion;magnetic resonance imaging;arterial spin labeling

YANG Yonggui*   CHEN Fang   WU Xiufen   LIN Huifang   YAN Gen  

Department of Radiology, the Second Affiliated Hospital of Xiamen Medical College, Xiamen 361021, China

Corresponding author: Yang YG, E-mail: yangyonggui125@sina.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS General Project of Natural Science Foundation of Fujian Province (No. 2022J011384); Training Project of the Youth and Middle-Aged Talents of Fujian Provincial Health Commission (No. 2020GGB067).
Received  2022-09-05
Accepted  2022-12-30
DOI: 10.12015/issn.1674-8034.2023.01.021
Cite this article as: YANG Y G, CHEN F, WU X F, et al. Feasibility study of fast arterial spin labeling imaging in brain on 3.0 T MRI scanner[J]. Chin J Magn Reson Imaging, 2023, 14(1): 116-123. DOI:10.12015/issn.1674-8034.2023.01.021.

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