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Clinical Article
Study of cerebral nuclei and white matter fibers in neonatal acute bilirubin encephalopathy based on diffusion tensor imaging
NIU Jin  YAN Ruifang  YIN Huijia  REN Jipeng  YUE Zheng  XIE Beichen  HAN Dongming 

Cite this article as: NIU J, YAN R F, YIN H J, et al. Study of cerebral nuclei and white matter fibers in neonatal acute bilirubin encephalopathy based on diffusion tensor imaging[J]. Chin J Magn Reson Imaging, 2023, 14(1): 67-71. DOI:10.12015/issn.1674-8034.2023.01.012.

[Abstract] Objective To investigate the value of diffusion tensor imaging (DTI) in the study of cerebral nuclei and white matter fibers in acute bilirubin encephalopathy (ABE).Materials and Methods Thirty full-term neonates with ABE were selected as the lesion group, and 30 normal full-term neonates were selected as the control group. All of them were examined by conventional MRI and DTI. The average diffusion coefficient (ADC), fractional anisotropy (FA) and isotropy (Iso) values of bilateral frontal lobe motor cortex, deep frontal lobe white matter, white matter above lateral ventricle, ventral thalamic nucleus, globus pallidus, posterior limb of internal capsule, splenium corporis callosi, subthalamic nucleus, red nucleus/substantia nigra, pontine nucleus, hippocampus, medulla oblongata and cerebellar dentate nucleus were measured and statistically analyzed respectively.Results Compared with the control group, ADC and Iso values were lower and FA values were higher in the bilateral frontal lobe motor cortex, posterior limb of internal capsule and dentate nucleus of the lesion group (P<0.05). And Iso values were lower in the bilateral white matter above bilateral lateral ventricle,globus pallidus, splenium corporis callosi, red nucleus/substantia nigra, pontine nucleus and hippocampus of the lesion group (P<0.05). There were no significant statistical difference in ADC, FA and Iso values in the bilateral frontal lobes deep white matter, ventral thalamic nucleus,subthalamic nucleus and medulla oblongata (P>0.05).Conclusions DTI suggests that the injury of cerebral nuclei and white matter fibers in ABE.
[Keywords] bilirubin encephalopathy;neonate;neural pathway;diffusion tensor imaging;magnetic resonance imaging

NIU Jin   YAN Ruifang*   YIN Huijia   REN Jipeng   YUE Zheng   XIE Beichen   HAN Dongming  

Department of Magnetic Resonance, the First Affiliated Hospital of Xinxiang Medical College, Xinxiang 453100, China

Corresponding author: Yan RF, E-mail:

Conflicts of interest   None.

ACKNOWLEDGMENTS Medical Science and Technology Research Program of Henan Province (No. LHGJ20200519).
Received  2022-09-12
Accepted  2022-11-29
DOI: 10.12015/issn.1674-8034.2023.01.012
Cite this article as: NIU J, YAN R F, YIN H J, et al. Study of cerebral nuclei and white matter fibers in neonatal acute bilirubin encephalopathy based on diffusion tensor imaging[J]. Chin J Magn Reson Imaging, 2023, 14(1): 67-71. DOI:10.12015/issn.1674-8034.2023.01.012.

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