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Clinical Article
Study on brain function changes in persistent postural-perceptual dizziness based on resting state functional magnetic resonance imaging
LIU Yueji  LIN Cunxin  XIAO Lijie  CHEN Zhengwei  LIU Tengfei  RONG Liangqun 

Cite this article as: LIU Y J, LIN C X, XIAO L J, et al. Study on brain function changes in persistent postural-perceptual dizziness based on resting state functional magnetic resonance imaging[J]. Chin J Magn Reson Imaging, 2023, 14(1): 41-47. DOI:10.12015/issn.1674-8034.2023.01.008.

[Abstract] Objective To analyze the changes in brain spontaneous functional activity in patients with persistent postural-perceptual dizziness (PPPD) in resting states and explore the pathogenesis of PPPD.Materials and Methods The patient group included 16 patients with PPPD who attended between April 2021 and April 2022. Sixteen patients with simultaneous physical examination who were the same age and sex as PPPD patients were enrolled in the control group. Other types of dizziness in patients were excluded by history, signs, electrography, head-shaking experiment, vestibular-induced myogenic potential, and imaging studies. They were subjected to the Dizziness Handicap Inventory, Hamilton Anxiety Scale, Hamilton Depression Scale, and resting state functional magnetic resonance imaging and computed the fractional amplitude of low frequency fluctuation (fALFF) and regional homogeneity (ReHo).Results The fALFF values of the left precuneus (t=4.52) in the patient group were significantly higher than in the control group (P<0.05), while the ReHo values in the left Brodmann area 48 (t=-7.61) and the left premotor cortex (t=-6.60) were significantly lower than in the control group (P<0.05).Conclusions Dysfunction of the precuneus in patients with PPPD may be associated with abnormal integration of visual and vestibular information; dysfunction of the left premotor cortex may be associated with worsening of symptoms during active and passive movement, and dysfunction of the left Brodmann area 48 may be associated with mood disorders in patients. The abnormality of spontaneous brain function activity in PPPD patients may be the cause of PPPD, which provides a new idea for the diagnosis and efficacy evaluation of PPPD patients.
[Keywords] persistent postural-perception dizziness;resting-state functional magnetic resonance imaging;blood oxygen levels dependent;magnetic resonance imaging;brain function;fractional amplitude of low frequency fluctuation;regional homogeneity;functional connectivity

LIU Yueji1, 2   LIN Cunxin1, 2   XIAO Lijie2   CHEN Zhengwei2   LIU Tengfei2   RONG Liangqun2*  

1 Xuzhou Medical University, Xuzhou 221004, China

2 Department of Neurology, the Second Affiliated Hospital of Xuzhou Medical University, Xuzhou 221006, China

Corresponding author: Rong LQ, E-mail:

Conflicts of interest   None.

ACKNOWLEDGMENTS Xuzhou Science and Technology Program Project (No. KC20077).
Received  2022-06-28
Accepted  2022-11-10
DOI: 10.12015/issn.1674-8034.2023.01.008
Cite this article as: LIU Y J, LIN C X, XIAO L J, et al. Study on brain function changes in persistent postural-perceptual dizziness based on resting state functional magnetic resonance imaging[J]. Chin J Magn Reson Imaging, 2023, 14(1): 41-47. DOI:10.12015/issn.1674-8034.2023.01.008.

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