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Research progress on the brain network mechanism of Chinese medicine rehabilitation therapy intervention in knee osteoarthritis
LIU Jun  LI Xingjie  WAN Yiwen  CHEN Shangjie  XIE Hongliang 

Cite this article as: Liu J, Li XJ, Wan YW, et al. Research progress on the brain network mechanism of Chinese medicine rehabilitation therapy intervention in knee osteoarthritis[J]. Chin J Magn Reson Imaging, 2022, 13(11): 161-164. DOI:10.12015/issn.1674-8034.2022.11.033.

[Abstract] Knee osteoarthritis (KOA) is an osteoarthritic disease that occurs in the elderly. Traditional exercise, acupuncture, and Tui-na rehabilitation therapies are clinical approaches to alleviate KOA. MRI shows that KOA is associated with changes in brain structure and functional networks such as cortical thinning and abnormal functional connectivity of brain regions. Chinese medicine rehabilitation therapy works by restoring abnormal changes in brain function and structure in KOA patients. Therefore, this review is based on MRI technology to review and summarize it: (1) KOA pain causes cortical thinning, gray matter volume, density reduction, and other abnormal changes in the structural network of the brain; (2) KOA shows changes in functional network such as abnormal activation of specific brain regions and abnormal changes in functional connectivity of different brain regions; (3) standardized exercise training can modulate brain networks; (4) acupuncture, moxibustion, and massage can improve the functional structure of multiple brain regions. To provide new ideas for promoting the combination of traditional Chinese medicine rehabilitation and imaging technology, and to relieve the symptoms of KOA and relieve the pain of patients with traditional Chinese medicine rehabilitation.
[Keywords] knee osteoarthritis;Chinese medicine rehabilitation therapy;acupuncture;kinesitherapy;cerebral network;magnetic resonance imaging;review

LIU Jun1   LI Xingjie1   WAN Yiwen2   CHEN Shangjie1, 2   XIE Hongliang2*  

1 Graduate School of Anhui University of Chinese Medicine, Hefei 230038, China

2 Department of Rehabilitation Medicine, Shenzhen Baoan Hospital Affiliated to Southern Medical University, Shenzhen 518101, China

Xie HL, E-mail:

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 81973922).
Received  2022-01-18
Accepted  2022-11-04
DOI: 10.12015/issn.1674-8034.2022.11.033
Cite this article as: Liu J, Li XJ, Wan YW, et al. Research progress on the brain network mechanism of Chinese medicine rehabilitation therapy intervention in knee osteoarthritis[J]. Chin J Magn Reson Imaging, 2022, 13(11): 161-164. DOI:10.12015/issn.1674-8034.2022.11.033.

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