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Original Article
Immediate brain effect of pushing Qiaogong point intervention on stage Ⅰ essential hypertension based on rs-fMRI
CHEN Dongnan  YE Senlin  SHI Yue  DUAN Zhengting  FENG Yue 

Cite this article as: Chen DN, Ye SL, Shi Y, et al. Immediate brain effect of pushing Qiaogong point intervention on stage I essential hypertension based on rs-fMRI[J]. Chin J Magn Reson Imaging, 2022, 13(11): 93-98. DOI:10.12015/issn.1674-8034.2022.11.017.

[Abstract] Objective To observe the immediate brain effect of pushing Qiaogong point intervention in patients with grade I essential hypertension (EH) by resting-state functional magnetic resonance imaging (rs-fMRI).Materials and Methods Fifteen EH patients and 15 healthy controls (HC) with no statistical difference in sex, age, height, weight and other baseline conditions were prospectively enrolled. Demographic data of the two groups were filled in before enrollment. Baseline rs-fMRI data, systolic and diastolic blood pressures were collected for both groups at the start of the experiment, followed by a 10 minute Qiaogong point intervention for the EH group, followed by a second MRI scan and final measurement of systolic and diastolic blood pressures. Amplitude of low frequency fluctuation (ALFF) was used to compare the ALFF values of EH group and HC group, and the changes of ALFF values before and after intervention. Pearson correlation analysis was used to analyze the correlation between the difference of ALFF value in brain region and blood pressure between two groups.Results Compared with HC group, ALFF value of left middle frontal gyrus (MFG.L) was significantly lower in EH group (Gaussian random field correction, voxel P<0.005, cluster P<0.05). ALFF value of left middle frontal gyrus was negatively correlated with systolic blood pressure (r=-0.627, P=0.012). There was no significant correlation with diastolic blood pressure (P>0.05). After intervention, the systolic blood pressure and diastolic blood pressure of hypertension group were significantly lower than those before treatment (t=3.61, P=0.003); (t=3.80, P=0.002). ALFF values were significantly increased in bilateral middle frontal gyrus (Gaussian random field correction, voxel P<0.005, cluster P<0.05).Conclusions Decreased brain activity in left middle frontal gyrus in hypertensive patients Qiaogong point that the onset of EH is accompanied by brain function damage. Pushing bridge arch can immediately regulate the ALFF value of MFG in EH patients, which may communicate with massage stimulation signal, activate the brain regulatory function, and thus improve blood pressure.
[Keywords] grade I essential hypertension;push Qiaogong point;resting-state functional magnetic resonance imaging;amplitude of low frequency fluctuation;middle frontal gyrus;immediate effect;magnetic resonance imaging

CHEN Dongnan   YE Senlin   SHI Yue   DUAN Zhengting   FENG Yue*  

College of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China

Feng Y, E-mail:

Conflicts of interest   None.

Received  2022-06-29
Accepted  2022-11-06
DOI: 10.12015/issn.1674-8034.2022.11.017
Cite this article as: Chen DN, Ye SL, Shi Y, et al. Immediate brain effect of pushing Qiaogong point intervention on stage I essential hypertension based on rs-fMRI[J]. Chin J Magn Reson Imaging, 2022, 13(11): 93-98.DOI:10.12015/issn.1674-8034.2022.11.017

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