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Clinical Article
Evaluation of magnetic resonance DWI-ADC value in assessing the early efficacy of neoadjuvant chemotherapy for conventional osteosarcoma
LI Yuzeng  MAIERHABA·Nuermaimaiti   XU Hui  ZHANG Shifeng 

Cite this article as: Li YZ, Maierhaba·NEMMT, Xu H, et al. Evaluation of magnetic resonance DWI-ADC value in assessing the early efficacy of neoadjuvant chemotherapy for conventional osteosarcoma[J]. Chin J Magn Reson Imaging, 2022, 13(11): 88-92, 136. DOI:10.12015/issn.1674-8034.2022.11.016.

[Abstract] Objective To investigate the value of different apparent diffusion coefficient (ADC) value of magnetic resonance diffusion-weighted imaging (DWI) and their rates of change in assessing the early efficacy of neoadjuvant chemotherapy for osteosarcoma.Materials and Methods Cases of twenty-three patients with osteosarcoma undergoing neoadjuvant chemotherapy (NAC) at the Affiliated Tumour Hospital of Xinjiang Medical University between January 2019 and March 2022 were collected, and conventional MRI and DWI were performed before NAC and after 4 cycles of chemotherapy to obtain different ADC value and its rate of change were obtained. Patients were divided into good histological response group and poor histological response group according to the pathological histological Huvos grading method of chemotherapy, and the statistical differences of different ADC value and their change rates between the two groups were compared.Results The differences in ADCmean, ADCmin, ADCmean/volume, ADCmin/volume before and after chemotherapy in the good histological response group were statistically significant, all P<0.05 (P values were 0.024, <0.001, 0.018, 0.046, respectively). The differences in ADCmean, ADCmin, ADCmin/volume before and after chemotherapy were statistically significant in the poor histological response group, all P<0.05 (P values were 0.005, <0.001, 0.020, respectively), while the differences in ADCmean/volume were not statistically significant (P=0.071, P>0.05). The differences in the rates of change of ADCmean, ADCmin, ADCmean/volume, and ADCmin/volume between the two groups were statistically significant (P=0.047, 0.006, 0.039, 0.015, all P<0.05). The area under the curve (AUC) of ADCmin rate of change by receiver operating characteristic (ROC) curve analysis was 0.938, which was higher than the rates of change of ADCmean, ADCmin/volume, and ADCmean/volume (0.783, 0.767, and 0.813, respectively).Conclusions Different ADC value and their rates of change are of great value in the early assessment of the efficacy of osteosarcoma, and the ADCmin rate of change has significant advantages in predicting the efficacy of osteosarcoma.
[Keywords] osteosarcoma;efficacy evaluation;neoadjuvant chemotherapy;area under the curve;apparent diffusion coefficient;diffusion weighted imaging;magnetic resonance imaging

LI Yuzeng   MAIERHABA·Nuermaimaiti    XU Hui*   ZHANG Shifeng  

Medical Imaging Center of Tumour Hospital Affiliated to Xinjiang Medical University, Urumqi 830011, China

Xu H, E-mail:

Conflicts of interest   None.

Received  2022-07-08
Accepted  2022-10-15
DOI: 10.12015/issn.1674-8034.2022.11.016
Cite this article as: Li YZ, Maierhaba·NEMMT, Xu H, et al. Evaluation of magnetic resonance DWI-ADC value in assessing the early efficacy of neoadjuvant chemotherapy for conventional osteosarcoma[J]. Chin J Magn Reson Imaging, 2022, 13(11): 88-92, 136. DOI:10.12015/issn.1674-8034.2022.11.016.

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