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Clinical Article
Value of T2* mapping MRI in quantitative assessment of diabetic macular edema with retinal hemorrhage
WANG Yehong  SHAO Juwei  LI Lei  LI Jianbo  ZHANG Liwei  XIONG Yuxin  YANG Ying  YANG Mengwei  SU Wei 

Cite this article as: Wang YH, Shao JW, Li L, et al. Value of T2* mapping MRI in quantitative assessment of diabetic macular edema with retinal hemorrhage[J]. Chin J Magn Reson Imaging, 2022, 13(11): 66-70, 81. DOI:10.12015/issn.1674-8034.2022.11.012.


[Abstract] Objective To investigate the value and feasibility of T2* mapping MRI in evaluating diabetic macular edema (DME).Materials and Methods Thirty patients (36 eyes) with DME (patient group) in the Affiliated Hospital of Yunnan University from October 2020 to December 2021 were prospectively enrolled,including a group of 26 eyes with retinal hemorrhage and a group of 10 eyes without retinal hemorrhage. Twenty healthy volunteers (39 eyes) were collected as the control group. Axial T2WI, coronal T2WI, sagittal T1WI and axial T2* mapping MRI were performed between the two groups. Six regions of interest (ROIs) were drawn at the retina region: optic disc sector, macula sector, the attachment point of lateral rectus muscle eye ring (temporal side), the attachment point of medial rectus muscle eye ring (nasal side), the midpoint of optic disc sector and temporal side (MOT), the midpoint of optic disc sector and nasal side (MON) and 6 ROIs were drawn in front of the retina (ROI size 1 mm2). Statistical analyses among multiple groups were conducted using one-way analysis of variance and the Kruskal-Wallis test.Results The T2* value of the retina region (optic disc sector, macula sector, temporal side, nasal side, MON, MOT) and those in front of the retina (macula sector, temporal side, nasal side, MON, MOT) was statistically significant between the retinal hemorrhage group and the control group (P<0.05). The T2* value of the retina region (optic disc sector, macula sector, MON, MOT) and those in front of the retina (macula sector, temporal side, nasal side, MOT) was statistically significant between the retinal hemorrhage group and the group without retinal hemorrhage (P<0.05). The T2* value of the retina region (optic disc sector, temporal side) was statistically significant between the group without retinal hemorrhage and the control group (P<0.05).Conclusions T2* mapping MRI can sensitively and quantitatively assess the retinal hemorrhage of DME, and has a high value in diagnosis, monitoring progression and therapeutic effect of DME.
[Keywords] diabetic macular edema;retinal hemorrhage;magnetic resonance imaging;functional magnetic resonance imaging;T2* mapping;quantitative assessment

WANG Yehong1   SHAO Juwei1   LI Lei1   LI Jianbo1   ZHANG Liwei2   XIONG Yuxin3   YANG Ying3   YANG Mengwei1   SU Wei1*  

1 Department of Radiology, the Affiliated Hospital of Yunnan University, Kunming 650021, China

2 Department of Ophthalmology, the Affiliated Hospital of Yunnan University, Kunming 650021, China

3 Department of Endocrinology, the Affiliated Hospital of Yunnan University, Kunming 650021, China.

Su W, E-mail: 13619634911@163.com

Conflicts of interest   None.

Received  2022-06-09
Accepted  2022-11-04
DOI: 10.12015/issn.1674-8034.2022.11.012
Cite this article as: Wang YH, Shao JW, Li L, et al. Value of T2* mapping MRI in quantitative assessment of diabetic macular edema with retinal hemorrhage[J]. Chin J Magn Reson Imaging, 2022, 13(11): 66-70, 81.DOI:10.12015/issn.1674-8034.2022.11.012

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