Share:
Share this content in WeChat
X
Original Articles
Comparative study on resting functional connection of amygdala between recurrent and first-episode depression
SUN Jifei  MA Yue  GUO Chunlei  LUO Yi  GAO Shanshan  CHEN Qingyan  HONG Yang  ZHANG Guolei  FANG Jiliang 

Cite this article as: Sun JF, Ma Y, Guo CL, et al. Comparative study on resting functional connection of amygdala between recurrent and first-episode depression[J]. Chin J Magn Reson Imaging, 2022, 13(10): 144-149. DOI:10.12015/issn.1674-8034.2022.10.022.


[Abstract] Objective To explore the functional connectivity (FC) alterations in RDE by comparing the resting-state FC differences in amygdala in recurrent depressive episodes (RDE) and first depressive episode (FDE) characteristics.Materials and Methods Twenty-one patients with RDE, patients with FDE, and healthy controls (HCs) were included, and resting-state brain function MRI data were collected from the 3 groups of subjects, and clinical depression, anxiety, and redundancy scales were completed. One-way ANOVA was used to compare the differences between bilateral amygdala and whole brain FC in the 3 groups, and the results were corrected for Gaussian random fields. Time series means (FC values) of the brain regions with differences in FC between the 3 groups were extracted and the results were Bonferroni corrected (P<0.016) for post hoc two-by-two comparisons of FC values. Finally, Pearson correlation analysis was performed between FC values and clinical scale scores for the statistically different brain regions among the 3 groups.Results (1) Compared with the FDE group, the FC of the left amygdala with the left and right anterior cingulate gyrus/left orbital part of the superior frontal gyrus was increased in the RDE group, and the FC of the right amygdala with the right precentral gyrus/right precuneus and right supplementary motor area/right middle cingulate gyrus was increased in the RDE group. Compared with the HC group, the FC of the left amygdala with the left and right anterior cingulate gyrus/left orbital part of the superior frontal gyrus was increased in the RDE group. (2) The FC values of the left amygdala and the left and right anterior cingulate/left orbital part of the superior frontal gyrus in the RDE group were positively correlated with the Rumination Response Scale (RRS) scores (r=0.460, P=0.033).Conclusions There were differences in FC between RDE and FDE in the amygdala and limbic circuits, reward circuit, somatosensory-motor areas and default mode network, and a more extensive FC alteration feature was present in RDE, which may be the reason why the neuropathological mechanism of RDE is more complex.
[Keywords] recurrent depressive episodes;first episode depression;amygdala;resting-state;magnetic resonance imaging;functional connection

SUN Jifei1   MA Yue1   GUO Chunlei1   LUO Yi1   GAO Shanshan1   CHEN Qingyan1   HONG Yang2   ZHANG Guolei2*   FANG Jiliang1*  

1 Functional Brain imaging Lab, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China

2 Department of Radiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China

Zhang GL, E-mail: glzhang2009@126.com Fang JL, E-mail: Fangmgh@163.com

Conflicts of interest   None.

Received  2021-11-24
Accepted  2022-10-13
DOI: 10.12015/issn.1674-8034.2022.10.022
Cite this article as: Sun JF, Ma Y, Guo CL, et al. Comparative study on resting functional connection of amygdala between recurrent and first-episode depression[J]. Chin J Magn Reson Imaging, 2022, 13(10): 144-149.DOI:10.12015/issn.1674-8034.2022.10.022

[1]
Brockbank J, Krause T, Moss E, et al. Health state utility values in major depressive disorder treated with pharmacological interventions: a systematic literature review[J/OL]. Health Qual Life Outcomes, 2021, 19(1) [2021-11-23]. https://pubmed.ncbi.nlm.nih.gov/33736649/. DOI: 10.1186/s12955-021-01723-x.
[2]
Cosci F, Mansueto G, Fava GA. Relapse prevention in recurrent major depressive disorder. A comparison of different treatment options based on clinical experience and a critical review of the literature[J]. Int J Psychiatry Clin Pract, 2020, 24(4): 341-348. DOI: 10.1080/13651501.2020.1779308.
[3]
Fava GA, Cosci F, Guidi J, et al. Well-being therapy in depression: New insights into the role of psychological well-being in the clinical process[J]. Depress Anxiety, 2017, 34(9): 801-808. DOI: 10.1002/da.22629.
[4]
Cheung EYW, Shea YF, Chiu PKC, et al. Diagnostic Efficacy of Voxel-Mirrored Homotopic Connectivity in Vascular Dementia as Compared to Alzheimer's Related Neurodegenerative Diseases-A Resting State fMRI Study[J/OL]. Life (Basel), 2021, 11(10) [2021-11-23]. https://pubmed.ncbi.nlm.nih.gov/34685479/. DOI: 10.3390/life11101108.
[5]
Wang X, Cheng B, Roberts N, et al. Shared and distinct brain fMRI response during performance of working memory tasks in adult patients with schizophrenia and major depressive disorder[J]. Hum Brain Mapp, 2021, 42(16): 5458-5476. DOI: 10.1002/hbm.25618.
[6]
Liu M, Li B, Hu D. Autism Spectrum Disorder Studies Using fMRI Data and Machine Learning: A Review[J/OL]. Front Neurosci, 2021, 15 [2021-11-23]. https://pubmed.ncbi.nlm.nih.gov/34602966/. DOI: 10.3389/fnins.2021.697870.
[7]
Sun J, Chen L, He J, et al. Altered Brain Function in First-Episode and Recurrent Depression: A Resting-State Functional Magnetic Resonance Imaging Study[J/OL]. Front Neurosci, 2022, 16 [2021-11-23]. https://pubmed.ncbi.nlm.nih.gov/35546875/. DOI: 10.3389/fnins.2022.876121.
[8]
Liu J, Fan YM, Zeng LL, et al. The neuroprogressive nature of major depressive disorder: evidence from an intrinsic connectome analysis[J/OL]. Transl Psychiatry, 2021, 11(1) [2021-11-23]. https://pubmed.ncbi.nlm.nih.gov/33542206/. DOI: 10.1038/s41398-021-01227-8.
[9]
Yüksel D, Dietsche B, Konrad C, et al. Neural correlates of working memory in first episode and recurrent depression: An fMRI study[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2018, 84(2): 39-49. DOI: 10.1016/j.pnpbp.2018.02.003.
[10]
Tien RD, Felsberg GJ, Krishnan R, et al. MR imaging of diseases of the limbic system[J]. AJR Am J Roentgenol, 1994, 163(3): 657-665. DOI: 10.2214/ajr.163.3.8079864.
[11]
Donnici C, Long X, Dewey D, et al. Prenatal and postnatal maternal anxiety and amygdala structure and function in young children[J/OL]. Sci Rep, 2021, 11(1) [2021-11-23]. https://pubmed.ncbi.nlm.nih.gov/33597557/. DOI: 10.1038/s41598-021-83249-2.
[12]
Tassone VK, Demchenko I, Salvo J, et al. Contrasting the amygdala activity and functional connectivity profile between antidepressant-free participants with major depressive disorder and healthy controls: A systematic review of comparative fMRI studies[J/OL]. Psychiatry Res Neuroimaging, 2022, 325 [2021-11-23]. https://pubmed.ncbi.nlm.nih.gov/35944425/. DOI: 10.1016/j.pscychresns.2022.111517.
[13]
Young KD, Siegle GJ, Zotev V, et al. Randomized Clinical Trial of Real-Time fMRI Amygdala Neurofeedback for Major Depressive Disorder: Effects on Symptoms and Autobiographical Memory Recall[J]. Am J Psychiatry, 2017, 174(8): 748-755. DOI: 10.1176/appi.ajp.2017.16060637.
[14]
Wang WW, Wu X. Cingulate gyrus: anatomy, physiology and epileptic seizure[J]. Chin J Contemp Neurol Neurosurg, 2018, 18(5): 315-323. DOI: 10.3969/j.issn.1672-6731.2018.05.004.
[15]
Dunlop BW, Mayberg HS. Neuroimaging-based biomarkers for treatment selection in major depressive disorder[J]. Dialogues Clin Neurosci, 2014, 16(4): 479-490. DOI: 10.31887/DCNS.2014.16.4/bdunlop.
[16]
Hayden BY, Pearson JM, Platt ML. Fictive reward signals in the anterior cingulate cortex[J]. Science, 2009, 324(5929): 948-950. DOI: 10.1126/science.1168488.
[17]
Workman CI, Lythe KE, McKie S, et al. Subgenual Cingulate-Amygdala Functional Disconnection and Vulnerability to Melancholic Depression[J]. Neuropsychopharmacology, 2016, 41(8): 2082-2090. DOI: 10.1038/npp.2016.8.
[18]
Jacobs RH, Barba A, Gowins JR, et al. Decoupling of the amygdala to other salience network regions in adolescent-onset recurrent major depressive disorder[J]. Psychol Med, 2016, 46(5): 1055-1067. DOI: 10.1017/S0033291715002615.
[19]
Jezzini A, Bromberg-Martin ES, Trambaiolli LR, et al. A prefrontal network integrates preferences for advance information about uncertain rewards and punishments[J]. Neuron, 2021, 109(14): 2339-2352. DOI: 10.1016/j.neuron.2021.05.013.
[20]
Gong L, Xu RH, Yang D, et al. Orbitofrontal Cortex Functional Connectivity-Based Classification for Chronic Insomnia Disorder Patients With Depression Symptoms[J/OL]. Front Psychiatry, 2022, 13 [2021-11-23]. https://pubmed.ncbi.nlm.nih.gov/35873230/. DOI: 10.3389/fpsyt.2022.907978.
[21]
Cheng W, Rolls ET, Qiu J, et al. Functional connectivity of the human amygdala in health and in depression[J]. Soc Cogn Affect Neurosci, 2018, 13(6): 557-568. DOI: 10.1093/scan/nsy032.
[22]
Quevedo K, Yuan Teoh J, Engstrom M, et al. Amygdala Circuitry During Neurofeedback Training and Symptoms' Change in Adolescents With Varying Depression[J/OL]. Front Behav Neurosci, 2020, 14 [2021-11-23]. https://pubmed.ncbi.nlm.nih.gov/32774244/. DOI: 10.3389/fnbeh.2020.00110.
[23]
Admon R, Holsen LM, Aizley H, et al. Striatal Hypersensitivity During Stress in Remitted Individuals with Recurrent Depression[J]. Biol Psychiatry, 2015, 78(1): 67-76. DOI: 10.1016/j.biopsych.2014.09.019.
[24]
Chen LM, Guo CL, Li XJ, et al. Preliminary study on comparing the ReHo features of resting-state functional MRI between the treatment-resistant and non-treatment-resistant depression[J]. Chin J Magn Imaging, 2021, 12(3): 10-14. DOI: 10.12015/issn.1674-8034.2021.03.003.
[25]
Zhou L, Tian N, Geng ZJ, et al. Diffusion tensor imaging study of brain precentral gyrus and postcentral gyrus during normal brain aging process[J/OL]. Brain Behav, 2020 [2021-11-23]. https://link.springer.com/content/pdf/10.1002/brb3.1758.pdf. DOI: 10.1002/brb3.1758.
[26]
Yun JY, Kim YK. Graph theory approach for the structural-functional brain connectome of depression[J/OL]. Prog Neuropsychopharmacol Biol Psychiatry, 2021, 111 [2021-11-23]. https://pubmed.ncbi.nlm.nih.gov/34265367/. DOI: 10.1016/j.pnpbp.2021.110401.
[27]
Li W, Wang C, Lan X, et al. Resting-state functional connectivity of the amygdala in major depressive disorder with suicidal ideation[J]. J Psychiatr Res, 2022, 153: 189-196. DOI: 10.1016/j.jpsychires.2022.07.001.
[28]
Martens M, Filippini N, Masaki C, et al. Functional Connectivity between Task-Positive Networks and the Left Precuneus as a Biomarker of Response to Lamotrigine in Bipolar Depression: A Pilot Study[J/OL]. Pharmaceuticals (Basel), 2021, 14(6) [2021-11-23]. https://pubmed.ncbi.nlm.nih.gov/34204977/. DOI: 10.3390/ph14060534.
[29]
Peng D, Liddle EB, Iwabuchi SJ, et al. Dissociated large-scale functional connectivity networks of the precuneus in medication-naïve first-episode depression[J]. Psychiatry Res, 2015, 232(3): 250-256. DOI: 10.1016/j.pscychresns.2015.03.003.
[30]
Zhang S, Cui J, Zhang Z, et al. Functional connectivity of amygdala subregions predicts vulnerability to depression following the COVID-19 pandemic[J]. J Affect Disord, 2021, 297(9): 421-429. DOI: 10.1016/j.jad.2021.09.107.
[31]
Albert K, Gau V, Taylor WD, et al. Attention bias in older women with remitted depression is associated with enhanced amygdala activity and functional connectivity[J]. J Affect Disord, 2017, 210: 49-56. DOI: 10.1016/j.jad.2016.12.010.

PREV Study on application value of proton density weighted imaging accelerated with artificial intelligence‐compressed sensing in assessing cartilage injury in osteoarthritis of the knee
NEXT Quantitative analysis of early changes in the myelin structure of rats with ischemic stroke using MRI signal intensity ratio and diffusion tensor imaging
  



Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn