Share:
Share this content in WeChat
X
Clinical Articles
Measurement of the diameter of retrobulbar optic nerve sheath in Chinese healthy adults by MRI and its related factors
LIU Chang  JI Haixia  TIAN Yanghua  XIE Yiju  WANG Lidan  DENG Kexue 

Cite this article as: Liu C, Ji HX, Tian YH, et al. Measurement of the diameter of retrobulbar optic nerve sheath in Chinese healthy adults by MRI and its related factors[J]. Chin J Magn Reson Imaging, 2022, 13(10): 103-107. DOI:10.12015/issn.1674-8034.2022.10.015.


[Abstract] Objective To evaluate the normal values of retrobulbar optic nerve sheath diameter (ONSD) in Chinese adults measured by MRI and analyze the potential factors affecting it.Materials and Methods The materials of healthy adults who underwent brain MRI examination for health screening between July 2017 and November 2020 were retrospective analyzed. The ONSD and eyeball transverse diameter (ETD) of each eye were measured at 3 mm behind the eye. Linear regression was used to determine the relationship between ONSD and the variables such as age, sex, height, weight, body mass index (BMI), mean arterial blood pressure (MABP), and ETD.Results A total of 413 subjects were included in the study. There were 227 males and 186 females, aged (42±12) years. The mean ONSD of 413 subjects was [4.76 (95% CI: 4.72-4.80)] mm. Upon simple linear regression analysis, we observed that the mean ONSD did vary with sex (P=0.002) and ETD (P=0.002). Further multiple linear regression analysis also showed that sex (P<0.001) and ETD (P=0.001) were associated with ONSD. The mean ONSD for males was (4.86±0.42) mm compared with (4.63±0.40) mm for females, which meant a significant difference between the two groups (P<0.001). We further assessed a normative value for the ONSD/ETD ratio, the mean value of which was 0.22 (95% CI: 0.21-0.22) mm.Conclusions This study established the range of MRI-based ONSD in healthy Chinese adults. Sex and ETD were the influencing factors of ONSD measurement. The difference in the ONSD value by sex suggest that separate normal reference ranges are need for men and women.
[Keywords] optic nerve sheath diameter;health;Chinese adult;intracranial pressure;magnetic resonance imaging

LIU Chang1   JI Haixia2   TIAN Yanghua2   XIE Yiju1   WANG Lidan1   DENG Kexue1*  

1 Department of Radiology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230036, China

2 Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei 230032, China

Deng KX, E-mail: dengkexue-anhui@163.com

Conflicts of interest   None.

Received  2022-06-08
Accepted  2022-09-28
DOI: 10.12015/issn.1674-8034.2022.10.015
Cite this article as: Liu C, Ji HX, Tian YH, et al. Measurement of the diameter of retrobulbar optic nerve sheath in Chinese healthy adults by MRI and its related factors[J]. Chin J Magn Reson Imaging, 2022, 13(10): 103-107.DOI:10.12015/issn.1674-8034.2022.10.015

[1]
Wen JJ, Wei JJ. Advances in the study of idiopathic intracranial hypertension[J]. Journal of the Chinese Academy of Medical Sciences, 2021, 43(2): 288-292. DOI: 10.3881/j.issn.1000-503X.12693.
[2]
Lee S, Kim YO, Baek JS, et al. The prognostic value of optic nerve sheath diameterin patients with subarachnoid hemorrhage[J/OL]. Crit Care, 2019, 23(1) [2022-06-07]. https://ccforum.biomedcentral.com/articles/10.1186/s13054-019-2360-6. DOI: 10.1186/s13054-019-2360-6.
[3]
Shokoohi H, Pyle M, Kuhl E, et al. Optic nerve sheath diameter measured by point-of-care ultrasound and MRI[J]. J Neuroimaging, 2020, 30(6): 793-799. DOI: 10.1111/jon.12764.
[4]
Liang Y, Wang J, Liu H, et al. Clinical study on non-invasive assessment of intracranial pressure after debridement in patients with acute heavy craniocerebraltrauma by transcranial colour doppler ultrasound[J]. Chinese Journal of Ultrasound Imaging, 2019, 28(6): 511-516. DOI: 10.3760/cma.j.issn.1004-4477.2019.06.009.
[5]
Wu CW, Huang XQ, Zou JF, et al. Correlation study between ultrasound measurement of optic nerve sheath diameter and intracranial pressure[J]. Chinese Journal of Microinvasive Neurosurgery, 2019, 24(9): 385-388. DOI: 10.11850/j.issn.1009-122X.2019.09.001.
[6]
Wang LJ, Yao Y, Feng LS, et al. Noninvasive and quantitative intracranial pressure estimation using ultrasonographic measurement of optic nerve sheath diameter[J/OL]. Sci Rep, 2017, 7 [2022-06-07]. https://www.nature.com/articles/srep42063. DOI: 10.1038/srep42063.
[7]
Schroeder C, Katsanos AH, Richter D, et al. Quantification of optic nerve and sheath diameter by transorbital sonography: a systematic review and metanalysis[J]. J Neuroimaging, 2020, 30(2): 165-174. DOI: 10.1111/jon.12691.
[8]
Kim DH, Jun JS, Kim R. Measurement of the optic nerve sheath diameter with magnetic resonance imaging and its association with eyeball diameter in healthy adults[J]. J Clin Neurol, 2018, 14(3): 345-350. DOI: 10.3988/jcn.2018.14.3.345.
[9]
Hawryluk GW, Nielson JL, Huie JR, et al. Analysis of normal high-frequency intracranial pressure values and treatment threshold in neurocritical care patients: insights into normal values and a potential treatment threshold[J]. JAMA Neurol, 2020, 77(9): 1150-1158. DOI: 10.1001/jamaneurol.2020.1310.
[10]
Bäuerle J, Schuchardt F, Schroeder L, et al. Reproducibility and accuracy of optic nerve sheath diameter assessment using ultrasound compared to magnetic resonance imaging[J/OL]. BMC Neurol, 2013, 13 [2022-06-07]. https://bmcneurol.biomedcentral.com/articles/10.1186/1471-2377-13-187. DOI: 10.1186/1471-2377-13-187.
[11]
Kerscher SR, Zipfel J, Groeschel S, et al. Comparison of b-scan ultrasound and MRI-based optic nerve sheath diameter (ONSD) measurements in children[J]. Pediatr Neurol, 2021, 124: 15-20. DOI: 10.1016/j.pediatrneurol.2021.08.002.
[12]
Han J, Chen DM, Li F, et alCT measurement of optic nerve sheath diameter to evaluate the prognosis of acute carbon monoxide poisoning[J] Chinese Emergency Medicine, 2021, 41(6): 465-469. DOI: 10.3969/j.issn.1002-1949.2021.06.002.
[13]
Vaiman M, Sigal T, Kimiagar I, et al. Noninvasive assessment of the intracranial pressure in non-traumatic intracranial hemorrhage[J]. J Clin Neurosci, 2016, 34: 177-181. DOI: 10.1016/j.jocn.2016.06.008.
[14]
Legros V, Lefour S, Bard M, et al. Optic nerve and perioptic sheath diameter (ONSD), eyeball transverse diameter (ETD) and ONSD/ETD ratio on MRI in large middle cerebral artery infarcts: a case-control study[J/OL]. J Stroke Cerebrovasc Dis, 2021, 30(3) [2022-06-07]. https://linkinghub.elsevier.com/retrieve/pii/S1052305720309186. DOI: 10.1016/j.jstrokecerebrovasdis.2020.105500.
[15]
Wang LJ, Zhang Y, Li C, et al. Ultrasonographic optic nerve sheath diameter as a noninvasive marker for intracranial hypotension[J/OL]. Ther Adv Neurol Disord, 2022, 15 [2022-06-07]. https://journals.sagepub.com/doi/10.1177/17562864211069744. DOI: 10.1177/17562864211069744.
[16]
Zhu S, Cheng C, Zhao D, et al. The clinical and prognostic values of optic nerve sheath diameter and optic nerve sheath diameter/eyeball transverse diameter ratio in comatose patients with supratentorial lesions[J/OL]. BMC Neurol, 2021, 21(1) [2022-06-07]. https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-021-02285-7. DOI: 10.1186/s12883-021-02285-7.
[17]
Lee SJ, Choi MH, Lee SE, et al. Optic nerve sheath diameter change in prediction of malignant cerebral edema in ischemic stroke: an observational study[J/OL]. BMC Neurol, 2020, 20(1) [2022-06-07]. https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-020-01931-w. DOI: 10.1186/s12883-020-01931-w.
[18]
Kim DH, Jun JS, Kim R. Ultrasonographic measurement of the optic nerve sheath diameter and its association with eyeball transverse diameter in 585 healthy volunteers[J/OL]. Sci Rep, 2017, 7(1) [2022-06-07]. https://www.nature.com/articles/s41598-017-16173-z. DOI: 10.1038/s41598-017-16173-z.
[19]
Stevens RRF, Gommer ED, Aries MJH, et al. Optic nerve sheath diameter assessment by neurosonology: A review of methodologic discrepancies[J]. J Neuroimaging, 2021, 31(5): 814-825. DOI: 10.1111/jon.12906.
[20]
Bekerman I, Sigal T, Kimiagar I, et al. The quantitative evaluation of intracranial pressure by optic nerve sheath diameter/eye diameter CT measurement[J]. Am J Emerg Med, 2016, 34(12): 2336-2342. DOI: 10.1016/j.ajem.2016.08.045.
[21]
Yee NP, Kashani S, Mailhot T, et al. More than meets the eye: point-of-care ultrasound diagnosis of acute optic neuritis in the emergency department[J/OL]. Am J Emerg Med, 2019, 37(1) [2022-06-07]. https://linkinghub.elsevier.com/retrieve/pii/S0735675718308118. DOI: 10.1016/j.ajem.2018.10.001.
[22]
Ji X, Xiao W, Ye H, et al. Ultrasonographic measurement of the optic nerve sheath diameter in dysthyroid optic neuropathy[J]. Eye (Lond), 2021, 35(2): 568-574. DOI: 10.1038/s41433-020-0904-2.
[23]
Yildiz G, Acar N, Cevik AA, et al. The evaluation of intracranial pressure evaluation by optic nerve sheath diameter measurement on bedside ultrasonography after ischemic stroke[J/OL]. Clin Neurol Neurosurg, 2021, 209 [2022-06-07]. https://linkinghub.elsevier.com/retrieve/pii/S0303846721004431. DOI: 10.1016/j.clineuro.2021.106914.
[24]
Su L, Li YC, Yu QL, et al. Relationship between the diameter of optic nerve sheath measured by bedside ultrasound and CT reconstruction and intracranial pressure[J]. Chin J CT & MRI, 2020, 18(1): 16-18. DOI: 10.3969/j.issn.1672-5131.2020.01.006.
[25]
Zhao MM. Research progress of multimodal imaging technology using optic nerve sheath diameter to monitor intracranial pressure[J]. Journal of Clinical and Pathology, 2021, 41(11): 2701-2705. DOI: 10.3978/j.issn.2095-6959.2021.11.033.
[26]
Beşir A, Tertemiz OF, Akdoğan A, et al. The importance of optic nerve sheath diameter in post-dural puncture headache diagnosis and follow-up[J]. Noro Psikiyatr Ars, 2019, 56(3): 195-199. DOI: 10.29399/npa.22883.
[27]
Zhu S, Cheng C, Zhao D, et al. The clinical and prognostic values of optic nerve sheath diameter and optic nerve sheath diameter/eyeball transverse diameter ratio in comatose patients with supratentorial lesions[J/OL]. BMC Neurol, 2021, 21(1) [2022-06-07]. https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-021-02285-7. DOI: 10.1186/s12883-021-02285-7.
[28]
Onder H, Goksungur G, Eliacik S, et al. The significance of ONSD, ONSD/ETD ratio, and other neuroimaging parameters in idiopathic intracranial hypertension[J]. Neurol Res, 2021, 43(12): 1098-1106. DOI: 10.1080/01616412.2021.1949688.
[29]
Goeres P, Zeiler FA, Unger B, et al. Ultrasound assessment of optic nerve sheath diameter in healthy volunteers[J]. J Crit Care, 2016, 31(1): 168-171. DOI: 10.1016/j.jcrc.2015.10.009.
[30]
Liu ZH, Zhang HJ, He XY, et al. Feasibility study of qualitative diagnosis of increased intracranial pressure based on the subarachnoid space of the optic nerve[J]. Chin J Radiol, 2019, 53(7): 555-558. DOI: 10.3760/cma.j.issn.1005-1201.2019.07.005.

PREV Differential diagnosis of atypical teratoid/rhabdoid tumor from medulloblastoma based on apparent diffusion coefficient and contrast-enhanced T1 weighted imaging histogram analysis
NEXT Diagnostic value of machine learning based on multi-parameters of MRI radiomics to predict cervical lymph node status of papillary thyroid carcinoma
  



Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn