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Clinical Articles
Differential diagnosis of atypical teratoid/rhabdoid tumor from medulloblastoma based on apparent diffusion coefficient and contrast-enhanced T1 weighted imaging histogram analysis
NIU Junxia  RAN Yuncai  CHEN Rui  QI Jinbo  WANG Xiao  BAI Jie  ZHANG Yong  CHENG Jingliang  ZHANG Yan 

Cite this article as: Niu JX, Ran YC, Chen R, et al. Differential diagnosis of atypical teratoid/rhabdoid tumor from medulloblastoma based on apparent diffusion coefficient and contrast-enhanced T1 weighted imaging histogram analysis[J]. Chin J Magn Reson Imaging, 2022, 13(10): 98-102, 120. DOI:10.12015/issn.1674-8034.2022.10.014.


[Abstract] Objective To explore the value of histogram analysis based on apparent diffusion coefficient (ADC) and contrast-enhanced T1 weighted imaging (CE-T1WI) in differentiating atypical teratoid/rhabdoid tumor (AT/RT) from medulloblastoma (MB).Materials and Methods A retrospective study includes 15 cases of AT/RT and 20 cases of MB confirmed by surgical histopathology and performed MRI examination from November 2013 to May 2021 in the First Affiliated Hospital of Zhengzhou University. Gender, age, location, maximum diameter, intra-tumoral cystic degeneration, intra-tumoral hemorrhage, obvious parenchymal enhancement and minimum ADC value of the two groups were recorded. MaZda software was used to delineate the region of interest (ROI) on the maximum tumor layer of ADC and CE-T1WI, and perform the gray histogram analysis. Nine histogram parameters were acquired. Independent sample t-test or Mann-Whitney U test was used to compare measurement data between the two groups, and Fisher's exact test was used to compare categorical data. A comprehensive model was established by screening histogram parameters with difference through logistic regression analysis. By drawing receiver operating characteristic (ROC) curve and calculating area under the curve (AUC), the differential diagnosis efficiencies of each parameter and the comprehensive model were evaluated.Results In ADC, skewness and Pere.01%, Pere.10% had statistically significant differences (P<0.05), and AUC were 0.701, 0.778 and 0.642, respectively. In CE-T1WI, variance is statistically significant (P<0.05), and AUC was 0.743. The comprehensive model established by logistic regression analysis showed AUC of 0.854, sensitivity of 68.8% and specificity of 88.9%.Conclusions The quantitative parameters obtained based on ADC and CE-T1WI histogram analysis of tumor maximum layer have certain value in preoperative differential diagnosis of AT/RT and MB, and provide a reference for the selection of clinical treatment.
[Keywords] atypical teratoid/rhabdoid tumor;medulloblastoma;magnetic resonance imaging;apparent diffusion coefficient;histogram analysis;differential diagnosis

NIU Junxia   RAN Yuncai   CHEN Rui   QI Jinbo   WANG Xiao   BAI Jie   ZHANG Yong   CHENG Jingliang   ZHANG Yan*  

Department of Magnetic Resonance, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China

Zhang Y, E-mail: fcczhangy61@zzu.edu.cn

Conflicts of interest   None.

Received  2022-07-14
Accepted  2022-10-13
DOI: 10.12015/issn.1674-8034.2022.10.014
Cite this article as: Niu JX, Ran YC, Chen R, et al. Differential diagnosis of atypical teratoid/rhabdoid tumor from medulloblastoma based on apparent diffusion coefficient and contrast-enhanced T1 weighted imaging histogram analysis[J]. Chin J Magn Reson Imaging, 2022, 13(10): 98-102, 120.DOI:10.12015/issn.1674-8034.2022.10.014

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