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High-resolution MRI feature of transient ischemic attack patients and its correlation with ABCD3 score
ZHOU Zhongkai  SHI Ying  ZHONG Di  REN Yibo  SUN Jiali  CHEN Yue  ZOU Wenxuan  SUI Ying  WANG Wei 

Cite this article as: Zhou ZK, Shi Y, Zhong D, et al. High-resolution MRI feature of transient ischemic attack patients and its correlation with ABCD3 score[J]. Chin J Magn Reson Imaging, 2022, 13(10): 91-97. DOI:10.12015/issn.1674-8034.2022.10.013.

[Abstract] Objective To investigate the differences in plaque characteristics between different ABCD3 scores and the correlation between ABCD3 scores and plaque characteristics in patients with transient ischemic attack (TIA) based on high-resolution MRI (HR-MRI).Materials and Methods Seventy-two patients underwent HR-MRI with TIA were retrospectively analyzed, which were divided into a low-intermediate risk group (ABCD3 score<6) and a high-risk group (ABCD3 score≥6). Two experienced radiologists independently identified plaque characteristics. Vascular area and lumen area, stenosis rate, normalized wall index (NWI), and remodeling index (RI) of the plaque or reference lumen were measured and calculated. Plaque enhancement was quantified according to the enhancement ratio (ER) after contrast: grade 0 (ERplaque≤ERreference vessel wall), grade 1 (ERreference vessel wall<ERplaque<ERpituitary infundibulum) and grade 2 (ERplaque≥ERpituitary infundibulum). Differences of clinical and plaque characteristics between groups were compared using t-test, Mann-Whitney U test, or chi-square test. Correlations between plaque characteristics and ABCD3 scores were analyzed by Spearman rank correlation or Pearson correlation.Results Seventy-two patients underwent HR-MRI with TIA were retrospectively analyzed, the NWI and RI in the high-risk group (n=39, 54.17%) were significantly higher than those in the low-to-intermediate-risk group (n=33, 45.83%) [0.86 (0.76, 0.92) vs. 0.62 (0.49, 0.75); 1.25 (1.05, 1.33) vs. 1.00 (0.81, 1.11); P<0.05]. The proportion of intraplaque hemorrhage (IPH) and grade 2 enhancement was significantly higher in the high-risk group than in the low-to-intermediate-risk group [74.4% vs. 33.3%; 56.4% vs. 6.1%; P<0.05]. The NWI (r=0.661, P<0.01), IPH (r=0.388, P<0.01), and plaque enhancement (r=0.467, P<0.01) were positively correlated with the ABCD3 score.Conclusions This study revealed different morphological characteristics of intracranial atherosclerotic plaques in patients with low-to-medium-risk and high-risk TIA. NWI, IPH and grade 2 enhancement are potential indicators to identify high-risk TIA patients. Probing these features with HR-MRI may provide insights into the early intervention of patients with TIA.
[Keywords] transient ischemic attack;ABCD3 score;atherosclerosis;plaque;early diagnosis;high-resolution magnetic resonance imaging;magnetic resonance angiography;diffusion weighted imaging;magnetic resonance imaging

ZHOU Zhongkai1   SHI Ying1   ZHONG Di2   REN Yibo2   SUN Jiali1   CHEN Yue1   ZOU Wenxuan1   SUI Ying1   WANG Wei1*  

1 Department of Magnetic Resonance, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China

2 Department of Neurology, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China

Wang W,

Conflicts of interest   None.

Received  2022-06-06
Accepted  2022-10-10
DOI: 10.12015/issn.1674-8034.2022.10.013
Cite this article as: Zhou ZK, Shi Y, Zhong D, et al. High-resolution MRI feature of transient ischemic attack patients and its correlation with ABCD3 score[J]. Chin J Magn Reson Imaging, 2022, 13(10): 91-97.DOI:10.12015/issn.1674-8034.2022.10.013

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