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Clinical Articles
Study on topology properties of white matter structure network in patients with amyotrophic lateral sclerosis
WANG Qiannan  ZHANG Jingna  HU Jun  WANG Li  QIAO Liang  ZHANG Ye  SANG Linqiong  LI Pengyue  OU Mingwen  QIU Mingguo 

Cite this article as: Wabg QN, Zhang JN, Hu J, et al. Study on topology properties of white matter structure network in patients with amyotrophic lateral sclerosis[J]. Chin J Magn Reson Imaging, 2022, 13(10): 86-90, 97. DOI:10.12015/issn.1674-8034.2022.10.012.


[Abstract] Objective To investigate the relationship between the integrity of brain structural network and motor and cognitive function in patients with amyotrophic lateral sclerosis (ALS).Materials and Methods Twenty-five ALS patients (ALS group) and twenty-six healthy subjects (healthy control group) matched in gender and age were prospectively collected pertaining to clinical data, neuropsychological scales and magnetic resonance diffusion tensor imaging (DTI) data. The whole brain structure network was constructed, and based on the graph theory, the differences between the ALS group and the healthy control group were compared. Pearson correlation analysis was further used to observe the changes of the structure network parameters and the correlation between the cognitive and motor function test scales.Results The local efficiency of white matter structure network in patients with ALS increased, and the Characteristic path length increased significantly (P<0.05). The node efficiency of frontal lobe, anterior cingulate gyrus, thalamus and other brain regions increased (P<0.05), the betweenness centrality of right anterior central gyrus, left wedge lobe and left posterior central gyrus decreased (P<0.05), but the betweenness centrality of left superior frontal gyrus and left inferior frontal gyrus increased (P<0.05). There was a negative correlation between the betweenness centrality of the left inferior frontal gyrus pars operculariscan and the ALSFAR-R score (r=-0.514, P=0.012).Conclusions The abnormal changes of the structure network of motor brain and extramotor brain in ALS patients may provide imaging basis for the diagnosis and prognosis evaluation of brain injury.
[Keywords] amyotrophic lateral sclerosis;diffusion tensor imaging;graph theory;magnetic resonance imaging;white matter structure network;topology properties

WANG Qiannan1   ZHANG Jingna1   HU Jun2   WANG Li1   QIAO Liang1   ZHANG Ye1   SANG Linqiong1   LI Pengyue1   OU Mingwen1   QIU Mingguo1*  

1 Department of Medical Imaging, College of Biomedical Engineering, Army medical university, Chongqing 400038, China

2 Department of Neurology, the First Affiliated Hospital of Army medical university, Chongqing Southwest Hospital, Chongqing 400038, China

Qiu MG, E-mail: qiumg_2002@sina.com

Conflicts of interest   None.

Received  2022-06-30
Accepted  2022-09-30
DOI: 10.12015/issn.1674-8034.2022.10.012
Cite this article as: Wabg QN, Zhang JN, Hu J, et al. Study on topology properties of white matter structure network in patients with amyotrophic lateral sclerosis[J]. Chin J Magn Reson Imaging, 2022, 13(10): 86-90, 97.DOI:10.12015/issn.1674-8034.2022.10.012

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