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Opportunities and challenges of diffusion spectrum magnetic resonance imaging: Achievements and prospects over the past decade in China
MAO Chunping  MAO Jiaji  ZHANG Xiang  WANG Mengzhu  YAN Xu  SHEN Jun 

Cite this article as: Mao CP, Mao JJ, Zhang X, et al. Opportunities and challenges of diffusion spectrum magnetic resonance imaging: Achievements and prospects over the past decade in China[J]. Chin J Magn Reson Imaging, 2022, 13(10): 37-45. DOI:10.12015/issn.1674-8034.2022.10.005.

[Abstract] Diffusion spectrum imaging (DSI) is an emerging advanced diffusion magnetic resonance imaging (dMRI) technology in recent years. Technologically, DSI is reconstructed model-freely, which applies the probability density function (PDF) to acquire diffusion signals in the entire q-space of water molecules within the voxels of human tissues, and uses high angular resolution to accurately detect the information of intricate crossing fibers within the tissues in vivo. DSI fiber tracking is currently the most reliable technique for tracking brain white matter fiber bundles. Conventional dMRI technology can only reflect part of the pathophysiological information of a certain disease. DSI technology can integrate multiple diffusion models into one model and ultimately obtain more comprehensive pathophysiological information of a certain disease. To date, the clinical application of DSI technology has been extended from brain diseases to body diseases initially and show good promise in the diagnosis and evaluation of diseases. However, the DSI technology has certain requirement of hardware of MRI unit. There are still some challenges on the genuinity and quantification of tractography derived from DSI. The optimized selection and combination of advanced diffusion models in certain disease remain to be determine through extended clinical application of DIS in the future. The postprocess technique of DSI is still necessary to be automatized and produced for promoting its wide clinical application in the diagnosis and therapy of different diseases. Herein, the achievements of Chinese scholars in the research of central nervous system diseases and body diseases by using DSI technology in the past decade were reviewed and the current challenges and future direction of DSI were summarized. The purpose is aimed to provide reference for better development of DSI technology and promote its extensive application in clinic.
[Keywords] central nervous system;cancer;Alzheimer's disease;Parkinson's disease;epilepsy;glioma;corticospinal tract injury;breast cancer;magnetic resonance imaging;diffusion spectrum imaging;q-space

MAO Chunping1   MAO Jiaji1   ZHANG Xiang1   WANG Mengzhu2   YAN Xu2   SHEN Jun1*  

1 Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China

2 MR Scientific Marketing, Siemens Medical Systems Co., Ltd, Shanghai 201318, China

Shen J, E-mail:

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 82171996, U1801681); Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme (2017).
Received  2022-09-06
Accepted  2022-10-14
DOI: 10.12015/issn.1674-8034.2022.10.005
Cite this article as: Mao CP, Mao JJ, Zhang X, et al. Opportunities and challenges of diffusion spectrum magnetic resonance imaging: Achievements and prospects over the past decade in China[J]. Chin J Magn Reson Imaging, 2022, 13(10): 37-45. DOI:10.12015/issn.1674-8034.2022.10.005.

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