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The value of diffusion kurtosis imaging in the early diagnosis of Parkinson's disease
DAI Kaifeng  CHEN Xiangrong  XU Shuhui  LIN qiansen  CAI Yali  CHEN Jieyun 

Cite this article as: Dai KF, Chen XR, Xu SH, et al. The value of diffusion kurtosis imaging in the early diagnosis of Parkinson's disease[J]. Chin J Magn Reson Imaging, 2022, 13(9): 81-85. DOI:10.12015/issn.1674-8034.2022.09.015.

[Abstract] Objective To explore the value of diffusion kurtosis imaging (DKI) in the early diagnosis of Parkinson's disease (PD).Materials and Methods Fifty patients with PD diagnosed by PD specialty in our hospital from January 2018 to June 2021 were randomly selected as PD group, and 50 healthy people who came to our hospital for physical examination at the same time were selected as healthy control (HC) group. The mean kurtosis (MK) value, axial kurtosis (Ka) value, radial kurtosis (Kr) value, mean diffusivity (MD) value, axial diffusivity (Da) value, radial diffusivity (Dr) value and fractional anisotropy (FA) value of brain nuclei DKI parameters in PD group and HC group were compared, and the correlation with Mini-mental State Examination (MMSE) score was compared.Results Except the Ka value of the red nucleus, the Kr value of the thalamus, putamen and globus pallidus, the other DKI parameters of the red nucleus, substantia nigra, thalamus, putamen, globus pallidus and caudate nucleus among the DKI parameters of the two groups were significantly different (P<0.05). The area under the curve (AUC) of the MK value of the red nucleus and substantia nigra in PD patients is the largest, followed by the MD value of substantia nigra, Ka value of substantia nigra, Dr value of substantia nigra and MK value of red nucleus according to the area under the curve (AUC). The AUC were 1.000, 0.992, 0.818, 0.808 and 0.791, respectively. The correlation analysis between DKI parameters and MMSE score showed that MK value of substantia nigra (r=0.572, P=0.043) and MD value (r=0.827, P=0.039), MK value of red nucleus (r=0.738, P=0.042) and MD value (r=0.899, P=0.031) are positively correlated with MMSE score, and there was no significant correlation between other DKI parameters and MMSE score.Conclusions The DKI can be used in the diagnosis of PD, and the parameters of substantia nigra DKI can be used as a priority index for the differential diagnosis of PD and guiding the severity of PD.
[Keywords] diffusion kurtosis imaging;Parkinson's disease;mean kurtosis;axial kurtosis;radial kurtosis;mean diffusivity;axial diffusivity;radial diffusivity;fractional anisotropy

DAI Kaifeng   CHEN Xiangrong   XU Shuhui   LIN qiansen   CAI Yali   CHEN Jieyun*  

Department of Imaging, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou 362000, China

*Chen JY, E-mail:

Conflicts of interest   None.

Received  2022-03-03
Accepted  2022-09-06
DOI: 10.12015/issn.1674-8034.2022.09.015
Cite this article as: Dai KF, Chen XR, Xu SH, et al. The value of diffusion kurtosis imaging in the early diagnosis of Parkinson's disease[J]. Chin J Magn Reson Imaging, 2022, 13(9): 81-85.DOI:10.12015/issn.1674-8034.2022.09.015

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