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Technical Article
Application of multi-shot echo planar imaging diffusion weighted imaging in the skull base
LUO Hedan  ZHANG Haonan  HU Shuai  LU Xulun  WANG Nan  MIAO Yanwei  LIU Ailian  LIN Liangjie  SONG Qingwei 

Cite this article as: Luo HD, Zhang HN, Hu S, et al. Application of multi-shot echo planar imaging diffusion weighted imaging in the skull base[J]. Chin J Magn Reson Imaging, 2022, 13(9): 75-80. DOI:10.12015/issn.1674-8034.2022.09.014.

[Abstract] Objective To explore the performance of image reconstruction using image-space sampling (IRIS)-based multi-shot echo planar imaging diffusion weighted imaging (MS-EPI DWI) for the skull base region.Materials and Methods Forty-nine volunteerss were recruited, with an average age of (42.00±19.39) years old. All subjects underwent conventional single-shot echo planar imaging diffusion weighted imaging (SS-EPI DWI) and IRIS-based multiple-shot diffusion-weighted imaging (8, 6, 4, and 2 shots, respectively). The apparent diffusion coefficient (ADC) values, signal to noise ratio (SNR) and contrast to noise ratio (CNR) of bilateral cerebellum, brainstem and pons were measured or calculated. A five-point scoring method was used by two observers to subjectively evaluate the image quality. The Kappa test was adopted to evaluate the consistency of the scores by the two observers. The differences of ADC, SNR, CNR and subjective scores among MS-EPI DWI with different number of shots and SS-EPI DWI were analyzed using Friedman test. If the differences were statistically significant, subsequent multiple comparisons were performed with Bonferroni correction for P values.Results The scores by the two observers were in good agreement (Kappa=0.795, 0.871, 0.782, 0.880, 0.847). Compared with different shot times of MS-EPI DWI, there was no significant difference in ADC between the two sides of the cerebellum, and there was statistical difference in the rest of the data (P<0.05). Compared with the SS-EPI DWI sequence, when the number of shots was 8, the ADC in the left brainstem and pons was smaller than that in the SS-EPI DWI (P<0.05), and when the number of shots was 4 and 2, the ADC in the bilateral brainstem and pons was smaller than that in the SS-EPI DWI (P<0.05). When the number of shots was 8, 6, and 2, the SNR, CNR and subjective scores of both sides of the cerebellum and pons and brain stem of MS-EPI DWI were higher than those of SS-EPI DWI. When the number of shots was 6, the SNR and CNR of the left cerebellum and pontine stem, the SNR and CNR of the right cerebellum, the SNR of the right pontine stem and subjective scores were significantly different from those of SS-EPI DWI (P<0.05).Conclusions Compared with SS-EPI DWI, MS-EPI DWI based on IRIS that showed higher SNR and lower geometric distortion compared with SS-EPI DWI. MS-EPI DWI shots 6 is recommended for clinical skull base between imaging time and image quality.
[Keywords] skull base;diffusion weighted imaging;image reconstruction using image-space sampling;magnetic resonance imaging;number of shots;multi-shot echo planar imaging

LUO Hedan1   ZHANG Haonan1   HU Shuai1   LU Xulun1   WANG Nan1   MIAO Yanwei1   LIU Ailian1   LIN Liangjie2   SONG Qingwei1*  

1 Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116000, China

2 Philips (China) Investment Co, Ltd., Shanghai 200072, China

*Song QW, E-mail:

Conflicts of interest   None.

ACKNOWLEDGMENTS Liaoning Provincial Department of Education Fund Project (No. LJKZ0856); Horizontal Project Fund Project (No. 2021HZ006).
Received  2022-06-13
Accepted  2022-08-19
DOI: 10.12015/issn.1674-8034.2022.09.014
Cite this article as: Luo HD, Zhang HN, Hu S, et al. Application of multi-shot echo planar imaging diffusion weighted imaging in the skull base[J]. Chin J Magn Reson Imaging, 2022, 13(9): 75-80. DOI:10.12015/issn.1674-8034.2022.09.014.

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