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Clinical Article
Quantitative assessment of bone marrow fat fraction of proximal femur in healthy subjects based on MRI mDIXON-Quant technique
WANG Ming  ZHANG Ping  BAI Lin  WANG Yali  HOU Zishuo  REN Congcong  ZHAO Jian 

Cite this article as: Wang M, Zhang P, Bai L, et al. Quantitative assessment of bone marrow fat fraction of proximal femur in healthy subjects based on MRI mDIXON-Quant technique[J]. Chin J Magn Reson Imaging, 2022, 13(9): 63-68. DOI:10.12015/issn.1674-8034.2022.09.012.

[Abstract] Objective The proton density fat fraction (PDFF) of bone marrow was obtained by MRI mDIXON-Quant sequence. The change trend of bone marrow fat content in the proximal femur of healthy subjects was observed, and the effects of age, gender and body mass index (BMI) on bone marrow fat content were detected.Materials and Methods From June 2021 to March 2022, a total of 227 patients aged 20-80 years were recruited for routine MRI examination and mDIXON-Quant examination of the proximal femur. The inclusion criteria and the image quality were satisfactory, with age of (53.59±14.20) years. The PDFF values of femoral head, femoral neck, greater trochanter and intertrochanter were obtained. Mann-Whitney U test was used to compare the difference of bone marrow PDFF values in different age groups and genders, and Kruskal-Wallis test was used to compare the bone marrow PDFF values in different regions. The Spearman correlation test was used to analyze correlations between age, gender, BMI and bone marrow PDFF, respectively. Finally, multiple linear regression analysis was performed on the PDFF values of each region of proximal femur with age, gender and BMI.Results The PDFF value of bone marrow in young and middle-aged subjects was lower than that in old subjects, and the PDFF value of each subregion was positively correlated with age (P<0.05). The bone marrow PDFF of males was higher than that of females in all of subregions (P<0.05). There were significant differences in PDFF between the subregions (P<0.05). The bone marrow PDFF of the greater trochanter was the highest. The femoral neck PDFF was the lowest.Conclusions The bone marrow fat content in proximal femur increased with age. The amount of bone marrow fat content in the proximal femur may be higher in men than in women. The content of bone marrow fat was different between subregions of proximal femur.
[Keywords] healthy subjects;proximal femur;bone marrow;fat quantification;mDIXON-Quant;proton density fat fraction;magnetic resonance imaging

WANG Ming   ZHANG Ping   BAI Lin   WANG Yali   HOU Zishuo   REN Congcong   ZHAO Jian*  

Department of CT/MR, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China

*Zhao J, E-mail:

Conflicts of interest   None.

Received  2022-05-23
Accepted  2022-09-14
DOI: 10.12015/issn.1674-8034.2022.09.012
Cite this article as: Wang M, Zhang P, Bai L, et al. Quantitative assessment of bone marrow fat fraction of proximal femur in healthy subjects based on MRI mDIXON-Quant technique[J]. Chin J Magn Reson Imaging, 2022, 13(9): 63-68.DOI:10.12015/issn.1674-8034.2022.09.012

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