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Clinical Article
The investigation of association between radiologic extranodal extension and pathological grades of prostate cancer
HAN Ye  REN Jing  XIAO Zunjian  JIAO Jianhua  QIN Weijun  CAO Qi  HUAN Yi 

Cite this article as: Han Y, Ren J, Xiao ZJ, et al. The investigation of association between radiologic extranodal extension and pathological grades of prostate cancer[J]. Chin J Magn Reson Imaging, 2022, 13(9): 41-45. DOI:10.12015/issn.1674-8034.2022.09.008.


[Abstract] Objective To investigate the correlation between radiologic extranodal extension (rENE) and prostate cancer Gleason score and International Society of Urological Pathology (ISUP) grades.Materials and Methods Ninety PCa N1 cases with integrated MRI and pathology data in Xijing Hospital affiliated to Air Force Medical University from January 2017 to June 2021 were selected. According to the presence or absence of rENE, they were divided into rENE+ and rENE- groups, of which 67 cases were in the rENE+ group and 23 cases in the rENE- group. The statistical differences between groups were analyzed using the Wilcoxon test. The correlation between rENE and Gleason scores, ISUP grades were evaluated by Spearman's rank correlation coefficient. Relative risk (RR) rate of ISUP grades was also calculated.Results The Gleason scores and ISUP grades in rENE+ patients were higher than rENE- patients, the statistical differences between two groups were significant. Patients in the rENE+ group were 2.6 times more likely to have ISUP 5 than those in the rENE- group (RR=2.6, 95% CI: 1.477-3.676) and patients in the rENE- group were 17.4 times more likely to have ISUP≤3 than those in the rENE+ group (RR=17.4, 95% CI: 4.2-72.3). The Spearman's rank correlation coefficient was 0.547 (95% CI: 0.363-0.688), 0.570 (95% CI: 0.367-0.716) in Gleason scores and ISUP grades.Conclusion rENE was moderately related to Gleason scores and ISUP grades. Compared to rENE- patients, rENE+ patients got higher Gleason scores and ISUP grades. rENE may be used to predict the degree of malignancy of PCa noninvasively.
[Keywords] prostate cancer;head and neck squamous cell carcinoma;metastasis of lymph nodes;extranodal extension;magnetic resonance imaging;Gleason score;International Society of Urological Pathology grade

HAN Ye1   REN Jing1*   XIAO Zunjian1   JIAO Jianhua2   QIN Weijun2   CAO Qi3   HUAN Yi1  

1 Department of Radiology, Xijing Hospital, Air Force Medical University, Xi'an 710032, China

2 Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an 710032, China

3 Department of Psychiatry, General Hospital of Xinjiang Military Command, Urumqi 830000, China

*Ren J, E-mail: jrenmm@126.com

Conflicts of interest   None.

Received  2022-03-01
Accepted  2022-09-06
DOI: 10.12015/issn.1674-8034.2022.09.008
Cite this article as: Han Y, Ren J, Xiao ZJ, et al. The investigation of association between radiologic extranodal extension and pathological grades of prostate cancer[J]. Chin J Magn Reson Imaging, 2022, 13(9): 41-45.DOI:10.12015/issn.1674-8034.2022.09.008

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