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Clinical Article
Correlation between intracranial volume parameters and cognitive impairment in idiopathic normal pressure hydrocephalus
KONG Shuangyan  LI Hongliang  WEI Youping  LIU Chunyan  LIU Lijuan  WU Yubing  LIU Xing  XING Yan 

Cite this article as: Kong SY, Li HL, Wei YP, et al. Correlation between intracranial volume parameters and cognitive impairment in idiopathic normal pressure hydrocephalus[J]. Chin J Magn Reson Imaging, 2022, 13(9): 7-12. DOI:10.12015/issn.1674-8034.2022.09.002.


[Abstract] Objective To investigate the correlation between cognitive impairment and intracranial volume parameters in patients with idiopathic normal pressure hydrocephalus (iNPH).Materials and Methods The clinical data were collected from Department of Neurology in Aviation General Hospital from January 2018 to February 2019. Thirty-seven iNPH cases were enrolled. Twenty controls with normal cognitive function matched with the age, gender and educational level of the study group were enrolled from health examination center. All subjects underwent cranial magnetic resonance imaging, Mini Mental State Examination (MMSE), Montreal Cognitive Assessment scale (MoCA). The total intracranial volume, cerebrospinal fluid (CSF) volume, gray matter volume and white matter volume were measured. The relative cerebrospinal fluid volume ratio, gray matter volume ratio and white matter volume ratio were calculated separately. Meanwhile, the Evan's index (EI) and callosal angle (CA) of all subjects were measured. The correlation of cerebrospinal fluid volume ratio, gray matter volume ratio and white matter volume ratio with MMSE and MoCA was analyzed.Results There were no significant differences (P>0.05) in age and sex between the iNPH group and the control group and there were significant differences (P<0.05) in EI, CA, gray matter volume ratio, white matter volume ratio and cerebrospinal fluid (CSF) volume ratio. White matter volume ratio was positively correlated with MMSE (r=0.492, P=0.001). The volume ratio of gray matter was negatively correlated with MMSE (r=-0.478, P=0.002). While CSF volume ratio, EI, CA were not correlated with MMSE. There was no correlation between intracranial volume parameters and MoCA.Conclusions The brain white matter volume ratio and gray matter volume ratio are related to cognitive dysfunction in patients with iNPH. The brain white matter volume ratio is negatively related to cognitive dysfunction and the brain gray matter volume ratio is positively related to cognitive dysfunction. When the brain white matter volume ratio is large, the cognitive dysfunction is relatively mild.When the brain gray matter volume ratio is large, the cognitive dysfunction is relatively serious. The measurement of brain white matter volume ratio and gray matter volume ratio can provide objective imaging evidence for the evaluation of cognitive dysfunction in iNPH.
[Keywords] idiopathic normal pressure hydrocephalus;magnetic resonance imaging;intracranial volume parameters;cognitive impairment;Mini Mental State Examination;Montreal Cognitive Assessment Scale

KONG Shuangyan   LI Hongliang   WEI Youping   LIU Chunyan   LIU Lijuan   WU Yubing   LIU Xing   XING Yan*  

Department of Neurology, Aviation General Hospital, Beijing 100012, China

*Xing Y, E-mail: drxingyan@163.com

Conflicts of interest   None.

Received  2022-02-05
Accepted  2022-08-25
DOI: 10.12015/issn.1674-8034.2022.09.002
Cite this article as: Kong SY, Li HL, Wei YP, et al. Correlation between intracranial volume parameters and cognitive impairment in idiopathic normal pressure hydrocephalus[J]. Chin J Magn Reson Imaging, 2022, 13(9): 7-12.DOI:10.12015/issn.1674-8034.2022.09.002

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