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Research progress of multimodal magnetic resonance imaging in glioma genotyping
GAO Weilin  WU Qiong 

Cite this article as: Gao WL, Wu Q. Research progress of multimodal magnetic resonance imaging in glioma genotyping[J]. Chin J Magn Reson Imaging, 2022, 13(8): 130-134. DOI:10.12015/issn.1674-8034.2022.08.029.


[Abstract] Glioma is the most common primary tumor of the central nervous system and is highly heterogeneous. Genotyping is important for the clinical treatment plan and prognosis of glioma. At present, the more mature and extensive genotypes are: isocitrate dehydrogenase (IDH), 1p/19q non-coding deletion, O6-methylguanine-DNA-methyltransferase (MGMT), telomerase reverse transcriptase (TERT), epidermal growth factor receptor (EGFR) and the like. Multimodal MRI such as diffusion tensor imaging (DTI), neurite orientation dispersion and density imaging (NODDI), mean apparent propagator (MAP)-MRI , amide proton transfer (ATP) imaging and 2-hydroxyglutarate magnetic resonance spectroscopy (2HG-MRS) can predict glioma genotyping from various aspects, thus guiding the next step treat. The T2-fluid attenuated inversion recovery (FLAIR) mismatch sign is a highly specific, low-sensitivity imaging marker for IDH-mutant astrocytoma with considerable potential for clinical application. This article reviews the research progress of these MRI techniques and T2-FLAIR mismatch sign in glioma genotyping.
[Keywords] glioma;genotyping;multimodality magnetic resonance imaging;T2-FLAIR mismatch sign

GAO Weilin   WU Qiong*  

Department of Radiology, the First Clinical Medical College of Inner Mongolia Medical University, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China

Wu Q, E-mail: 33360023@qq.com

Conflicts of interest   None.

Received  2022-04-20
Accepted  2022-07-26
DOI: 10.12015/issn.1674-8034.2022.08.029
Cite this article as: Gao WL, Wu Q. Research progress of multimodal magnetic resonance imaging in glioma genotyping[J]. Chin J Magn Reson Imaging, 2022, 13(8): 130-134.DOI:10.12015/issn.1674-8034.2022.08.029

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