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Interhemispheric voxel-mirrored homotopic connectivity in patients with type 2 diabetes
GAN Fan  ZHOU Shuilian  LIU Hui  ZHONG Yulin 

Cite this article as: Gan F, Zhou SL, Liu H, et al. Interhemispheric voxel-mirrored homotopic connectivity in patients with type 2 diabetes[J]. Chin J Magn Reson Imaging, 2022, 13(8): 71-74. DOI:10.12015/issn.1674-8034.2022.08.013.


[Abstract] Objective This study aimed to investigate the hemispheric homunculus functional connectivity in type 2 diabetes mellitus (T2DM) patients using the voxel mirror homunculus connection (VMHC) method.Materials and Methods This was a cross-sectional study, according to the inclusion criteria, 22 patients with T2DM from the Jiangxi Provincial People's Hospital from August 2020 to December 2021 were selected to the T2DM group and 22 healthy controls recruited from the community (sex, age and education level matched with patients in the T2DM group) were selected to the normal control group. Both groups underwent 3.0 T MRI scans, and then applied DPABI_V4.0 software and SPM8 to preprocess the MRI data, the differences in whole brain mirror homologous connections between the two groups of subjects were analyzed by the VMHC method, the differences in VMHC values between the two groups were analyzed by a paired two-sample t-test and the correlation between mean standardized VMHC values and fasting glucose values in significantly different brain regions was analyzed.Results Compared to healthy controls, VMHC values were higher in the diabetic group (GRF corrected, P<0.001 for voxel level, P<0.05 for cluster level) in both cerebellar lobule Ⅸ regions, and the mean standardized VMHC values in the differential brain regions did not correlate significantly with fasting glucose values (P>0.05).Conclusions The abnormalities in the functional connectivity of the bilateral cerebellar hemispheres with homunculus in T2DM patients may provide a reference for the pathogenesis of brain injury in T2DM patients.
[Keywords] voxel-mirrored homotopic connectivity;type 2 diabetes mellitus;magnetic resonance imaging;cerebellar hemisphere;brain injury

GAN Fan1, 2   ZHOU Shuilian2   LIU Hui2   ZHONG Yulin2*  

1 Medical College of Nanchang University, Nanchang 330000, China

2 Department of Ophthalmology, Jiangxi Provincial People's Hospital, the First Affiliated Hospital of Nanchang Medical College, Nanchang 330000, China

Zhong YL, E-mail: 804722489@qq.com

Conflicts of interest   None.

Received  2022-04-26
Accepted  2022-07-30
DOI: 10.12015/issn.1674-8034.2022.08.013
Cite this article as: Gan F, Zhou SL, Liu H, et al. Interhemispheric voxel-mirrored homotopic connectivity in patients with type 2 diabetes[J]. Chin J Magn Reson Imaging, 2022, 13(8): 71-74.DOI:10.12015/issn.1674-8034.2022.08.013

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