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Clinical Article
The value of quantitative assessment of lumbar disc degeneration with T2 mapping: A Meta analysis
ZHANG Xuyin  GUO Yinxia  PAXON Julien Michael  ABDETA Bogale Girma  DU Yonghao  NIU Gang 

Cite this article as: Zhang XY, Guo YX, Paxon JM, et al. The value of quantitative assessment of lumbar disc degeneration with T2 mapping:A Meta analysis[J]. Chin J Magn Reson Imaging, 2022, 13(8): 55-59, 70. DOI:10.12015/issn.1674-8034.2022.08.010.


[Abstract] Objective To quantitatively evaluate the changes in nucleus pulposus T2 relaxation time of lumbar disc degeneration using Meta analysis.Materials and Methods Retrieved the literatures from the library construction to October 31 2021 published in the Cochrane Library, PubMed, EMBASE, Wanfang Data, CQVIP, China National Knowledge Infrastructure (CNKI) databases applying T2 mapping method to assess lumbar disc degeneration. RevMan 5.3 and Stata1 5.0 softwares were used to calculate the weighted mean difference (WMD) and 95% confidential interval (CI) of the T2 relaxation time of nucleus pulposus between different gardes of lumbar disc degeneration.Results Thirteen articles were included, inlcuding 362 grade Ⅰ lumbar intervertebral discs, 1418 grade Ⅱ lumbar intervertebral discs, 1006 grade Ⅲ lumbar intervertebral discs, 548 grade Ⅳ lumbar intervertebral discs, and 201 grade Ⅴ lumbar intervertebral discs. The T2 relaxation time of the lumbar intervertebral disc nucleus pulposus gradually decreased with the increase of the lumbar intervertebral disc grade. The grade Ⅰ T2 relaxation time is significantly higher than the grade Ⅱ T2 relaxation time (WMD=35.58, 95% CI: 29.96-41.21, P<0.01), and the grade Ⅱ T2 relaxation time is significantly higher than the grade Ⅲ T2 relaxation time (WMD=32.93, 95% CI: 25.61-40.25, P<0.01), the grade Ⅲ T2 relaxation time is significantly higher than the grade Ⅳ T2 relaxation time (WMD=26.52, 95% CI: 20.88-32.15, P<0.01), the grade Ⅳ T2 relaxation time is higher than the grade Ⅴ (WMD=4.23, 95% CI: 2.00-6.46, P<0.01).Conclusions The T2 relaxation time of the nucleus pulposus can distinguish different degrees of degeneration of the lumbar intervertebral disc. T2 mapping can be used as an imaging examination to assist in the diagnosis of early degeneration of the lumbar intervertebral disc.
[Keywords] T2 mapping;T2 relaxation time;magnetic resonance imaging;lumbar;intervertebral disc degeneration;Meta analysis

ZHANG Xuyin   GUO Yinxia   PAXON Julien Michael   ABDETA Bogale Girma   DU Yonghao   NIU Gang*  

Department of Radiology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China

Niu G, E-mail: niugang369@126.com

Conflicts of interest   None.

Received  2022-01-13
Accepted  2022-08-10
DOI: 10.12015/issn.1674-8034.2022.08.010
Cite this article as: Zhang XY, Guo YX, Paxon JM, et al. The value of quantitative assessment of lumbar disc degeneration with T2 mapping:A Meta analysis[J]. Chin J Magn Reson Imaging, 2022, 13(8): 55-59, 70.DOI:10.12015/issn.1674-8034.2022.08.010

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