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Clinical Article
Quantitative assessment of microsatellite instability in endometrial cancer by T2 mapping combined with mDixon-Quant multiparameter imaging
MA Changjun  TIAN Shifeng  CHEN Lihua  SONG Qingling  SONG Qingwei  LIN Liangjie  LIU Ailian 

Cite this article as: Ma CJ, Tian SF, Chen LH, et al. Quantitative assessment of microsatellite instability in endometrial cancer by T2 mapping combined with mDixon-Quant multiparameter imaging[J]. Chin J Magn Reson Imaging, 2022, 13(8): 48-54. DOI:10.12015/issn.1674-8034.2022.08.009.

[Abstract] Objective To explore the application value of T2 mapping combined with mDixon-Quant multiparameter imaging in quantitative assessment of microsatellite instability (MSI) in endometrial cancer (EC).Materials and Methods The imaging data of 34 EC patients who were pathologically confirmed in our hospital from June 2019 to September 2021 were retrospectively analyzed. All patients underwent 3.0 T magnetic resonance imaging examination two weeks before surgery, and the scanning sequence included T1WI, T2WI, T2 mapping, mDixon-Quant, etc. Two observers independently and blindly measured the T2 value of the lesion T2 mapping sequence and the fat fraction (FF) value, R2* value and T2* value of the mDixon-Quant sequence. The intra-class correlation coefficient (ICC) was used to evaluate the consistency of the measurement results between the two observers, and the independent samples t-test or Mann-Whitney U test was used to compare the differences of each parameter value. The efficacy of parameters to predict EC MSI status was assessed using receiver operating characteristic (ROC) curves. The Delong test was used to compare the differences among the area under the curves (AUCs).Results The agreement between the two observers' measurements was good (ICC>0.75). The R2* value and T2 value of the MSI group were higher than those of the microsatellite stabilization (MSS) group, and the T2* value of the MSI group was lower than that of the MSS group, and the differences were statistically significant (P<0.05). The AUC values of R2* value, T2* value, T2 value and the combined parameters for evaluating the MSI status of EC were 0.773, 0.761, 0.780 and 0.939, respectively; the results of Delong test showed that there was no significant difference in the AUC of each single parameter for evaluating the MSI status of EC (P>0.05). There is a statistically significant difference between the AUC of the combined parameter to assess the EC MSI status and the AUC of the single parameter to assess the EC MSI status (P<0.05).Conclusions Both mDixon-Quant and T2 mapping multi-parameter imaging can quantitatively evaluate EC MSI status. The combination of the two can significantly improve the prediction performance and has a good clinical application prospect.
[Keywords] endometrial cancer;microsatellite instability;T2 mapping;mDixon-Quant;magnetic resonance imaging

MA Changjun1, 2   TIAN Shifeng1, 2   CHEN Lihua1, 2   SONG Qingling1, 2   SONG Qingwei1, 2   LIN Liangjie3   LIU Ailian1, 2*  

1 Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

2 Dalian Medical Imaging Artificial Intelligence Engineering Technology Research Center, Dalian 116011, China

3 Philips (China) Investment Co, Ltd., Shanghai 200040, China

Liu AL, E-mail:

Conflicts of interest   None.

Received  2022-03-22
Accepted  2022-08-05
DOI: 10.12015/issn.1674-8034.2022.08.009
Cite this article as: Ma CJ, Tian SF, Chen LH, et al. Quantitative assessment of microsatellite instability in endometrial cancer by T2 mapping combined with mDixon-Quant multiparameter imaging[J]. Chin J Magn Reson Imaging, 2022, 13(8): 48-54.DOI:10.12015/issn.1674-8034.2022.08.009

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