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Clinical Article
The value of apparent diffusion coefficient value in evaluating the IDH-1 mutation status and tumor cell proliferation activity of lower-grade gliomas
LIU Xianwang  KE Xiaoai  ZHOU Qing  LI Shenglin  DENG Juan  XUE Caiqiang  HUANG Xiaoyu  SUN Qiu  ZHOU Junlin 

Cite this article as: Liu XW, Ke XA, Zhou Q, et al. The value of apparent diffusion coefficient value in evaluating the IDH-1 mutation status and tumor cell proliferation activity of lower-grade gliomas[J]. Chin J Magn Reson Imaging, 2022, 13(8): 13-18. DOI:10.12015/issn.1674-8034.2022.08.003.

[Abstract] Objective To investigate the evaluation value of apparent diffusion coefficient (ADC) value in lower-grade gliomas (LGG) isocitrate dehydrogenase 1 (IDH-1) mutation status and tumor cell proliferation activity.Materials and Methods Forty-four patient cases with LGG were confirmed by pathology, and measured IDH-1 mutation status and the Ki-67 proliferation index was retrospectively analyzed, including 24 cases of IDH-1 mutant-type and 20 cases of IDH-1 wild-type. The minimum ADC value (ADCmin), mean ADC value (ADCmean) of the lesion parenchyma, and the ADC value of the contralateral mirror normal white matter on the ADC maps were measured, and the relative minimum ADC value (rADCmin) and relative mean ADC value (rADCmean) were calculated. The differences in ADC values between the two groups were compared, and receiver operating characteristic (ROC) curves were drawn to evaluate the differential diagnostic efficacy. The Ki-67 proliferation index of the solid tumor components was also measured to explore its relationship with ADC values.Results The ADCmin, ADCmean, rADCmin, and rADCmean values in the IDH-1 mutant-type group were higher than those in the IDH-1 wild-type group, and the differences between the groups were statistically significant (all P<0.05). ROC results show that all parameters can effectively distinguish IDH-1 mutant-type and IDH-1 wild-type LGG. Among them, rADCmin has the best discrimination efficiency, and 0.978 is the best cut-off value, with area under the curve (AUC), sensitivity, specificity, accuracy, positive predictive value, and negative predictive value was 0.838, 80.00%, 83.33%, 81.82%, 80.00%, and 83.30%, respectively. ADCmin, ADCmean, rADCmin, rADCmean and Ki-67 proliferation index showed different degrees of negative correlation (r=-0.552, -0.590, -0.532, -0.579, all P<0.05).Conclusions ADC values can be used to evaluate LGG IDH-1 mutation status, and it also has a certain value for evaluating tumor cell proliferation activity.
[Keywords] brain gliomas;lower-grade gliomas;isocitrate dehydrogenase;Ki-67 proliferation index;magnetic resonance imaging;apparent diffusion coefficient

LIU Xianwang   KE Xiaoai   ZHOU Qing   LI Shenglin   DENG Juan   XUE Caiqiang   HUANG Xiaoyu   SUN Qiu   ZHOU Junlin*  

Department of Radiology, Lanzhou University Second Hospital; Second Clinical School, Lanzhou University; Key Laboratory of Medical Imaging of Gansu Province; Gansu International Scientific and Technological Cooperation Base of Medical Imaging Artificial Intelligence, Lanzhou 730030, China

Zhou JL, E-mail:

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 81772006, 82071872); Natural Science Foundation of Gansu Province (No. 21JR11RA105); Open Fund of Gansu Provincial Key Laboratory of Medical Imaging (No. GSYX202007).
Received  2021-11-14
Accepted  2022-07-27
DOI: 10.12015/issn.1674-8034.2022.08.003
Cite this article as: Liu XW, Ke XA, Zhou Q, et al. The value of apparent diffusion coefficient value in evaluating the IDH-1 mutation status and tumor cell proliferation activity of lower-grade gliomas[J]. Chin J Magn Reson Imaging, 2022, 13(8): 13-18. DOI:10.12015/issn.1674-8034.2022.08.003.

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