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Original Article
Brain complexity in the patients of Parkinson's disease with depression: a resting-state functional magnetic resonance imaging study
LI Haidong  WANG Jun  NIU Jinliang 

Cite this article as: Li HD, Wang J, Niu JL. Brain complexity in the patients of Parkinson's disease with depression: a resting-state functional magnetic resonance imaging study[J]. Chin J Magn Reson Imaging, 2022, 13(7): 90-95. DOI:10.12015/issn.1674-8034.2022.07.016.


[Abstract] Objective To investigate the change of brain regions complexity by permutation entropy (PE), and to explore the imaging markers of characteristics in the patients of Parkinson's disease (PD) with depression.Materials and Methods Forty-five PD patients [twenty-two Parkinson's disease with depression (PD-Dep) patients, twenty-three Parkinson's disease patients without depression (PD-NDep) patients] and twenty-three healthy controls (HCs) were enrolled prospectively from 2020 to 2021 in the Second Hospital of Shanxi Medical University. All participants underwent resting state functional magnetic resonance imaging (rs-fMRI) scan. The progression of disease of patients was measured by 24-item Hamilton Depression Scale (HAMD-24) and Mini-Mental State Examination (MMSE) following each MRI scan. Permutation entropy (PE) was used to explore the complexity of various brain regions in the three groups. At the same time, the correlation between PE value and scale's score in PD-Dep group were analyzed.Results Age, gender, education and MMSE score showed no significant differences among the three groups (P>0.05). HAMD score in the PD-Dep group was significantly higher than that in the other two groups (P<0.01). PE value showed significant differences in the right inferior temporal gyrus, left anterior cingulate and right median cingulate gyrus among the three groups. PE values of PD-Dep group were increased in the right median cingulate gyrus than those of PD-NDep group (P=0.007). PE values of PD-Dep group were increased in the right inferior temporal gyrus than those of HCs group (P=0.022). PE values of PD-Dep group were decreased in the left anterior cingulate gyrus than those of HCs group (P=0.007). PE values of PD-NDep group were increased in the right inferior temporal gyrus than those of HCs group (P=0.004). The PE values of PD-NDep group were decreased in the left anterior cingulate and right median cingulate gyrus than those of HCs group (P<0.01, P=0.019). In addition, the HAMD score was significantly correlated with the PE value of the right median cingulate gyrus (P<0.01, r=0.790).Conclusions Permutation entropy can reflect the pathophysiological process of brain complexity changes in patients with PD-Dep. PE value in the right median cingulate gyrus may be an important indicator for evaluating disease progression. Permutation entropy may help provide reference information for early diagnosis, treatment and curative effect evaluation.
[Keywords] Parkinson's disease;depression;functional magnetic resonance imaging;permutation entropy;complexity;functional brain imaging;blood oxygen level dependent;pathological mechanism

LI Haidong   WANG Jun   NIU Jinliang*  

Department of Magnetic Resonance Imaging, the Second Hospital of Shanxi Medical University, Taiyuan 030001, China

Niu JL, E-mail: sxlscjy@163.com

Conflicts of interest   None.

Received  2022-03-01
Accepted  2022-07-06
DOI: 10.12015/issn.1674-8034.2022.07.016
Cite this article as: Li HD, Wang J, Niu JL. Brain complexity in the patients of Parkinson's disease with depression: a resting-state functional magnetic resonance imaging study[J]. Chin J Magn Reson Imaging, 2022, 13(7): 90-95.DOI:10.12015/issn.1674-8034.2022.07.016

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