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Original Article
Preliminary study on brain network of patients with somatic symptom disorder based on probabilistic fiber tracking
DONG Liao  LIANG Huaibin  YANG Guang  LIU Jianren  DU Xiaoxia 

Cite this article as: Dong L, Liang HB, Yang G, et al. Preliminary study on brain network of patients with somatic symptom disorder based on probabilistic fiber tracking[J]. Chin J Magn Reson Imaging, 2022, 13(7): 80-83, 130. DOI:10.12015/issn.1674-8034.2022.07.014.


[Abstract] Objective Based on diffusion tensor imaging (DTI), probabilistic fiber tracking was carried out to construct the brain structural network, and the network topological properties were calculated to explore whether the patients with somatic symptom disorder (SSD) are abnormal in the brain structural network.Materials and Methods Thirty right-handed SSD patients and 30 healthy controls were recruited to participate in magnetic resonance scanning to obtain DWI and T1 weighted high-resolution structural images. DTI metrics were calculated and the brain structural network was constructed by the probabilistic fiber tracking method, taking 90 regions of the AAL 90 template as nodes. The clustering coefficient, characteristic path length, small-worldness, global efficiency, local efficiency, and degree centrality of each node of the structural network were calculated. Two sample t-test was used to compare the differences between groups, and the correlation between the network topological parameter and the disease duration, scales was analyzed.Results The results demonstrated that both SSD patients and heathy controls had small-world topology in white matter (WM) network. Further analysis revealed that SSD patients' local and global efficiency were significantly and the clustering coefficient were significantly lower than that of healthy controls (P<0.05), and the characteristic path length was significantly higher than that of healthy controls (P<0.05). There was no significant difference between the two groups in the small-worldness.Conclusions We revealed the abnormal topological organization of WM network in SSD, suggesting that the brain's ability to integrate information and the interconnection between local regions were weakened, which may be related to the abnormality of self-perception and body perception function in patients with SSD. This study may improve our understanding of the neural mechanism of SSD from the WM topological organization level.
[Keywords] somatic symptom disorder;brain network;magnetic resonance image;probabilistic tractography;diffusion tensor imaging

DONG Liao1   LIANG Huaibin2   YANG Guang1   LIU Jianren2*   DU Xiaoxia3*  

1 Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, Shanghai 200062, China

2 Department of Neurology, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China

3 School of Psychology, Shanghai University of Sport, Shanghai 200438, China

Du XX, E-mail: duxiaoxia@sus.edu.cn Liu JR, E-mail: liujr021@ sjtu.edu.cn

Conflicts of interest   None.

Received  2022-04-28
Accepted  2022-07-01
DOI: 10.12015/issn.1674-8034.2022.07.014
Cite this article as: Dong L, Liang HB, Yang G, et al. Preliminary study on brain network of patients with somatic symptom disorder based on probabilistic fiber tracking[J]. Chin J Magn Reson Imaging, 2022, 13(7): 80-83, 130.DOI:10.12015/issn.1674-8034.2022.07.014

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