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Original Article
Uncoupling between functional connectivity density and amplitude of low frequency fluctuation in childhood absence epilepsy
YU Qianqian  LIU Gaoping  XU Qiang  ZHANG Qirui  LU Guangming  ZHANG Zhiqiang 

Cite this article as: Yu QQ, Liu GP, Xu Q, et al. Uncoupling between functional connectivity density and amplitude of low frequency fluctuation in childhood absence epilepsy[J]. Chin J Magn Reson Imaging, 2022, 13(7): 75-79, 89. DOI:10.12015/issn.1674-8034.2022.07.013.

[Abstract] Objective To observe the changes of amplitude of low frequency fluctuation (ALFF) and functional connectivity density (FCD) in childhood absence epilepsy (CAE), which would assist to elucidate the its clinical and pathophysiological mechanism.Materials and Methods Thirty-seven CAE patients and fifty age-and sex-matched healthy controls underwent resting-state functional magnetic resonance imaging (rs-fMRI) scanning, the clinical data were collected. The whole brain mappings of ALFF, FCD and ALFF-FCD were calculated and two-sample t-tests were employed to detect significant differences of these index. Across-voxel correlation analysis was used to calculate the correlation between the brain areas with significant differences for ALFF, FCD and ALFF-FCD. Additionally, correlation analysis was performed between these index and the duration of the disease in CAE patients.Results Compared with the control group, the CAE group showed a reverse change pattern of ALFF and FCD in specific brain areas: the increased ALFF and decreased FCD in bilateral thalamus, while the ALFF of default mode network such as precuneus and bilateral inferior parietal lobules decreased and the FCD increased (GRF correction, voxel-P<0.01, cluster-P<0.05). Correlation analysis revealed that in CAE, the correlation coefficient of ALFF and FCD in thalamus (r=0.374, P=0.022) decreased compared with control group (r=0.448, P=0.001), and there was a significant difference (t=-2.095, P=0.020); In addition, the index of amplitude subtracting connectivity (ALFF-FCD value) in thalamus was negatively correlated with the duration of disease (r=-0.473, P<0.001).Conclusions The thalamus and default mode brain regions showed significant functional changes by different rs-fMRI indexes, reflecting that they are important brain regions involved in the pathophysiological mechanism of childhood absence epilepsy.
[Keywords] childhood absence epilepsy;amplitude of low frequency fluctuation;functional connection density;uncoupling;resting-state functional magnetic resonance imaging

YU Qianqian   LIU Gaoping   XU Qiang   ZHANG Qirui   LU Guangming   ZHANG Zhiqiang*  

Department of Diagnostic Radiology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China

Zhang ZQ, E-mail:

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 81790653, 81871345).
Received  2021-10-14
Accepted  2022-03-07
DOI: 10.12015/issn.1674-8034.2022.07.013
Cite this article as: Yu QQ, Liu GP, Xu Q, et al. Uncoupling between functional connectivity density and amplitude of low frequency fluctuation in childhood absence epilepsy[J]. Chin J Magn Reson Imaging, 2022, 13(7): 75-79, 89. DOI:10.12015/issn.1674-8034.2022.07.013.

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