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Clinical Article
Value of MRI histogram in the differential diagnosis of dysembryoplastic neuroepithelial tumor and diffuse astrocytoma
ZHAO Wei  DING Shuang  HANJIAERBIEKE·Kukun   WANG Baolong  WANG Yunling 

Cite this article as: Zhao W, Ding S, Hanjiaerbieke·K , et al. Value of MRI histogram in the differential diagnosis of dysembryoplastic neuroepithelial tumor and diffuse astrocytoma[J]. Chin J Magn Reson Imaging, 2022, 13(7): 17-21,54. DOI:10.12015/issn.1674-8034.2022.07.004.


[Abstract] Objective To explore the value of the MRI histogram analysis in differential diagnosis of dysembryoplastic neuroepithelial tumor (DNET) and diffuse astrocytoma (DA).Materials and Methods The general clinical data and imaging findings of 21 patients with DNET and 35 patients with DA who underwent surgery and were confirmed by pathological biopsy in the Department of Neurosurgery of the First Affiliated Hospital of Xinjiang Medical University from December 2014 to December 2021 were retrospectively analyzed. The conventional imaging features of the two groups were first analyzed, and then the tumors in their preoperative MRI T2 fluid attenuated inversion recovery axial images were outlined and subjected to histogram analysis, and histogram parameters such as mean, median, standard deviation, heterogeneity, kurtosis, skewness and entropy of the tumors were extracted, and the histogram parameters of DNET and DA were compared and statistically analyzed to observe and compare the function of each parameter for disease diagnosis.Results General information such as age, gender and tumor site of DNET and DA patients were compared, and the differences were not statistically significant (P>0.05). The inverted triangle sign imaging sign was statistically significant for differential diagnosis between the two groups of patients (P<0.05). The difference between the mean, median and kurtosis of DNET and DA was found to be statistically significant (P<0.05), with kurtosis having the greatest univariate differential diagnostic value, with an area under the curve (AUC) value of 0.690 for the receiver operating characteristic curve and sensitivity and specificity of 68.6% and 66.7%, respectively. The AUC of mean combined with kurtosis was the highest, and the AUC, sensitivity and specificity were 0.721, 66.7% and 77.1%, respectively. Therefore, the differential diagnostic efficacy of mean combined with kurtosis was higher than that of individual histogram analysis parameters. The differential diagnostic efficacy of combining the inverse triangle sign with the histogram analysis parameters was significantly improved, and the mean, median, and kurtosis combined with the inverse triangle sign had the best differential diagnostic efficacy, with an AUC value of 0.830, sensitivity, specificity, and accuracy of 85.7%, 74.3%, and 78.6%, respectively.Conclusions For DNET and DA, which are difficult to distinguish on preoperative MRI, the histogram analysis technique combined with the inverted triangle sign can provide a more accurate differential diagnosis of the two.
[Keywords] dysembryoplastic neuroepithelial tumor;diffuse astrocytoma;histogram analysis;magnetic resonance imaging;differential diagnosis

ZHAO Wei   DING Shuang   HANJIAERBIEKE·Kukun    WANG Baolong   WANG Yunling*  

Nuclear Magnetic Resonance Room, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China

Wang YL, E-mail: 1079806994@qq.com

Conflicts of interest   None.

Received  2022-04-23
Accepted  2022-05-05
DOI: 10.12015/issn.1674-8034.2022.07.004
Cite this article as: Zhao W, Ding S, Hanjiaerbieke·K , et al. Value of MRI histogram in the differential diagnosis of dysembryoplastic neuroepithelial tumor and diffuse astrocytoma[J]. Chin J Magn Reson Imaging, 2022, 13(7): 17-21,54.DOI:10.12015/issn.1674-8034.2022.07.004

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