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Research progress in the application of chemical exchange saturation transfer imaging in glioma

Cite this article as: Zhang L, Wang J. Research progress in the application of chemical exchange saturation transfer imaging in glioma[J]. Chin J Magn Reson Imaging, 2022, 13(6): 139-142. DOI:10.12015/issn.1674-8034.2022.06.029.

[Abstract] Glioma is the most common primary central nervous system tumor with strong invasiveness and poor prognosis. Its growth is accompanied by changes in the contents of protein, glutamic acid, amine and other substances. Chemical exchange saturation transfer (CEST) imaging is a novel and noninvasive MRI mechanism, relying on the exchange between the mobile protons in amide (-NH), amine (-NH2) and hydroxyl (-OH) and bulk water. It can reflect the changes of the mobile protons content in the protein or peptide and pH value in the tissue at the molecular level. It can detect and quantify changes within gliomas at the molecular level. In this article, the principle, the applications in the diagnosis and classification, grading, molecular typing prediction and response evaluation of gliomas and the shortcoming of CEST were reviewed.
[Keywords] glioma;chemical exchange saturation transfer;magnetic resonance imaging;grading;molecular typing prediction;response evaluation

ZHANG Lan1, 2   WANG Jing1, 2*  

1 Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China

2 Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430030, China

Wang J, E-mail:

Conflicts of interest   None.

ACKNOWLEDGMENTS General Program of Natural Science Foundation of Hubei Province (No. 2021CFB447).
Received  2022-03-10
Accepted  2022-04-24
DOI: 10.12015/issn.1674-8034.2022.06.029
Cite this article as: Zhang L, Wang J. Research progress in the application of chemical exchange saturation transfer imaging in glioma[J]. Chin J Magn Reson Imaging, 2022, 13(6): 139-142. DOI:10.12015/issn.1674-8034.2022.06.029.

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