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Original Article
Resting-state functional magnetic resonance imaging in patients with nocturnal enuresis
GAO Tingting  WANG Mengxing  TANG Wei  DONG Liao  YANG Guang  DU Xiaoxia  MA Jun 

Cite this article as: Gao TT, Wang MX, Tang W, et al. Resting-state functional magnetic resonance imaging in patients with nocturnal enuresis[J]. Chin J Magn Reson Imaging, 2022, 13(6): 71-75. DOI:10.12015/issn.1674-8034.2022.06.014.

[Abstract] Objective To explore the mechanism of spontaneous brain activity in children with nocturnal enuresis (NE) by resting-state functional magnetic resonance imaging (rs-fMRI).Materials and Methods NE (n=37) and healthy controls (n=37) matched by gender, age, and education were recruited. All subjects underwent brain rs-fMRI scanning. The resting-state data calculated the regional homogeneity (ReHo) and degree centrality (DC) of children with NE and the healthy control group. A two-sample t-test compared the differences between the two groups. The DC value and ReHo value of brain areas with differences between the two groups were extracted for correlation analysis with clinical indicators and the score of Children's Sleep Habits Questionnaire (CSHQ).Results The results of the t-test showed that compared with the healthy control group, the DC value of the NE group decreased in the anterior cingulate gyrus and parahippocampal gyrus of the limbic lobe; Compared with healthy controls, the ReHo value of NE group in the anterior cingulate gyrus decreased. Correlation analysis showed that the DC value of the parahippocampal gyrus was positively correlated with the score of abnormal sleep (P=0.045, r=0.256); Correlation analysis showed that the DC value of the parahippocampal gyrus was positively correlated with the score of CSHQ (P=0.010, r=0.062).Conclusions The study shows that the decrease of local brain function activity in children with NE at rest may be closely related to the pathology of enuresis.
[Keywords] nocturnal enuresis;regional homogeneity;degree centrality;functional magnetic resonance imaging;anterior cingulate gyrus;parahippocampal gyrus

GAO Tingting1   WANG Mengxing2   TANG Wei1   DONG Liao1   YANG Guang1   DU Xiaoxia3*   MA Jun4*  

1 Department of Physics, Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai 200062, China

2 College of Medical imaging, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China

3 School of Psychology, Shanghai University of Sport, Shanghai 200438, China

4 Department of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China

Du XX, E-mail: Ma J, E-mail:

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 81901720).
Received  2022-03-10
Accepted  2022-05-31
DOI: 10.12015/issn.1674-8034.2022.06.014
Cite this article as: Gao TT, Wang MX, Tang W, et al. Resting-state functional magnetic resonance imaging in patients with nocturnal enuresis[J]. Chin J Magn Reson Imaging, 2022, 13(6): 71-75. DOI:10.12015/issn.1674-8034.2022.06.014.

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