Share:
Share this content in WeChat
X
Original Article
fMRI research on regional homogeneity and functional connectivity changes of brain regions in patients with end-stage renal disease
BAI Di  MA Chi  WANG Chengjian  ZHOU Tong  WANG Jiachen  BI Yuzhen  REN Yande 

Cite this article as: Bai D, Ma C, Wang CJ, et al. fMRI research on regional homogeneity and functional connectivity changes of brain regions in patients with end-stage renal disease[J]. Chin J Magn Reson Imaging, 2022, 13(6): 66-70. DOI:10.12015/issn.1674-8034.2022.06.013.


[Abstract] Objective To investigate the alterations of neuronal functional activity in patients with end-stage renal disease (ESRD) by using regional homogeneity (ReHo) and functional connectivity (FC) algorithm based on resting-state functional magnetic resonance imaging (rs-fMRI), and to analyze the association between spontaneous brain activity changes and blood biochemical index.Materials and Methods Thirty-six patients with ESRD and 32 healthy controls were scanned with rs-fMRI to calculate the ReHo value of the whole brain. Brain areas with altered ReHo values were selected as regions of interest for FC analysis. Two independent sample t tests was used for comparison between groups, and Pearson's correlation analysis was used between altered ReHo values and blood biochemical index.Results Compared with the healthy controls, ESRD patients showed the ReHo values in left temporal pole, right orbital inferior frontal gyrus and bilateral rectus gyrus were significantly increased (P<0.001, AlphaSim corrected), meanwhile, the ReHo values in bilateral calcarine sulcus, left inferior frontal gyrus, right superior temporal gyrus and supramarginal gyrus were significantly decreased (P<0.001, AlphaSim corrected). ESRD patients showed decreased FC between right calcarine sulcus and left inferior frontal gyrus and right supramarginal gyrus (P<0.05, NBS corrected). We also found decreased FC between right supramarginal gyrus and right superior temporal gyrus (P<0.01, NBS corrected). Correlation analyses showed that ReHo values in right calcarine sulcus were positively correlated with haemoglobin levels (r=0.347, P=0.048) and haematocrit (r=0.357, P=0.041).Conclusion ESRD patients had dyssynchrony of local functional activities in several brain regions, mainly involving the default mode network, which may contribute to further understanding of the neuropathological mechanism of brain injury in ESRD patients.
[Keywords] end-stage renal disease;resting-state functional magnetic resonance imaging;brain injury;regional homogeneity;functional connectivity

BAI Di1   MA Chi2   WANG Chengjian1   ZHOU Tong1   WANG Jiachen1   BI Yuzhen1   REN Yande1*  

1 Department of Radiology, the Affiliated Hospital of Qingdao University, Qingdao 266000, China

2 Department of Radiology, Qilu Hospital of Shandong University, Qingdao 266000, China

Ren YD, E-mail: 8198458ryd@qdu.edu.cn

Conflicts of interest   None.

Received  2022-03-02
Accepted  2022-05-31
DOI: 10.12015/issn.1674-8034.2022.06.013
Cite this article as: Bai D, Ma C, Wang CJ, et al. fMRI research on regional homogeneity and functional connectivity changes of brain regions in patients with end-stage renal disease[J]. Chin J Magn Reson Imaging, 2022, 13(6): 66-70.DOI:10.12015/issn.1674-8034.2022.06.013

[1]
Drew DA, Weiner DE, Sarnak MJ. Cognitive impairment in CKD: pathophysiology, management, and prevention[J]. Am J Kidney Dis, 2019, 74(6): 782-790. DOI: 10.1053/j.ajkd.2019.05.017.
[2]
Park BS, Kim SE, Lee HJ, et al. Alterations in structural and functional connectivities in patients with end-stage renal disease[J]. J Clin Neurol, 2020, 16(3): 390-400. DOI: 10.3988/jcn.2020.16.3.390.
[3]
Ma SH, Zhang M, Liu Y, et al. Abnormal rich club organization in end-stage renal disease patients before dialysis initiation and undergoing maintenance hemodialysis[J]. BMC Nephrol, 2020, 21(1): 515. DOI: 10.1186/s12882-020-02176-y.
[4]
Li C, Su HH, Qiu YW, et al. Regional homogeneity changes in hemodialysis patients with end stage renal disease: in vivo resting-state functional MRI study[J]. PLoS One, 2014, 9(2): e87114. DOI: 10.1371/journal.pone.0087114.
[5]
Li P, Ding D, Ma XY, et al. Altered intrinsic brain activity and memory performance improvement in patients with end-stage renal disease during a single dialysis session[J]. Brain Imaging Behav, 2018, 12(6): 1640-1649. DOI: 10.1007/s11682-018-9828-x.
[6]
Cole DM, Smith SM, Beckmann CF. Advances and pitfalls in the analysis and interpretation of resting-state FMRI data[J]. Front Syst Neurosci, 2010, 4: 8. DOI: 10.3389/fnsys.2010.00008.
[7]
Chen HJ, Qi RF, Kong X, et al. The impact of hemodialysis on cognitive dysfunction in patients with end-stage renal disease: a resting-state functional MRI study[J]. Metab Brain Dis, 2015, 30(5): 1247-1256. DOI: 10.1007/s11011-015-9702-0.
[8]
Ali I, Donne RL, Kalra PA. A validation study of the kidney failure risk equation in advanced chronic kidney disease according to disease aetiology with evaluation of discrimination, calibration and clinical utility[J]. BMC Nephrol, 2021, 22(1): 194. DOI: 10.1186/s12882-021-02402-1.
[9]
Wang JH, Wang XD, Xia MR, et al. GRETNA: a graph theoretical network analysis toolbox for imaging connectomics[J]. Front Hum Neurosci, 2015, 9: 386. DOI: 10.3389/fnhum.2015.00386.
[10]
Xia MR, Wang JH, He Y. BrainNet Viewer: a network visualization tool for human brain connectomics[J]. PLoS One, 2013, 8(7): e68910. DOI: 10.1371/journal.pone.0068910.
[11]
Serin E, Zalesky A, Matory A, et al. NBS-Predict: a prediction-based extension of the network-based statistic[J]. NeuroImage, 2021, 244: 118625. DOI: 10.1016/j.neuroimage.2021.118625.
[12]
Hu SH, Xu DR, Peterson BS, et al. Association of cerebral networks in resting state with sexual preference of homosexual men: a study of regional homogeneity and functional connectivity[J]. PLoS One, 2013, 8(3): e59426. DOI: 10.1371/journal.pone.0059426.
[13]
Hirakata H, Yao H, Osato S, et al. CBF and oxygen metabolism in hemodialysis patients: effects of anemia correction with recombinant human EPO[J]. Am J Physiol, 1992, 262(5Pt 2): F737-F743. DOI: 10.1152/ajprenal.1992.262.5.F737.
[14]
Chen PN, Wu BL, Hu RY, et al. Relation between cognitive impairment and brain regional homogeneity in patients with end-stage renal disease[J]. Chin J Neuromedicine, 2019, 18(1): 55-60. DOI: 10.3760/cma.j.issn.1671-8925.2019.01.010.
[15]
Lynch JC, Mountcastle VB, Talbot WH, et al. Parietal lobe mechanisms for directed visual attention[J]. J Neurophysiol, 1977, 40(2): 362-389. DOI: 10.1152/jn.1977.40.2.362.
[16]
Mesulam MM. A cortical network for directed attention and unilateral neglect[J]. Ann Neurol, 1981, 10(4): 309-325. DOI: 10.1002/ana.410100402.
[17]
Toussaint L, Indelicato DJ, Muren LP, et al. Temporal lobe sparing radiotherapy with photons or protons for cognitive function preservation in paediatric craniopharyngioma[J]. Radiother Oncol, 2020, 142: 140-146. DOI: 10.1016/j.radonc.2019.08.002.
[18]
Peng C, Yang H, Ran Q, et al. Immediate abnormal intrinsic brain activity patterns in patients with end-stage renal disease during a single dialysis session: resting-state functional MRI study[J]. Clin Neuroradiol, 2021, 31(2): 373-381. DOI: 10.1007/s00062-020-00915-0.
[19]
Liang X, Wen JQ, Ni L, et al. Altered pattern of spontaneous brain activity in the patients with end-stage renal disease: a resting-state functional MRI study with regional homogeneity analysis[J]. PLoS One, 2013, 8(8): e71507. DOI: 10.1371/journal.pone.0071507.
[20]
Li J, Curley WH, Guerin B, et al. Mapping the subcortical connectivity of the human default mode network[J]. NeuroImage, 2021, 245: 118758. DOI: 10.1016/j.neuroimage.2021.118758.
[21]
Luo S, Qi RF, Wen JQ, et al. Abnormal intrinsic brain activity patterns in patients with end-stage renal disease undergoing peritoneal dialysis: a resting-state functional MR imaging study[J]. Radiology, 2016, 278(1): 181-189. DOI: 10.1148/radiol.2015141913.
[22]
Ma C, Gao S, Li W, et al. Study on the changes of spontaneous brain activity in maintenance hemodialysis patients with end-stage renal disease based on three different resting state-functional magnetic resonance low-frequency amplitude algorithms[J]. Natl Med J China, 2021, 101(4): 265-270. DOI: 10.3760/cma.j.cn112137-20200513-01524.
[23]
Chen HJ, Qiu J, Fu QQ, et al. Alterations of spontaneous brain activity in hemodialysis patients[J]. Front Hum Neurosci, 2020, 14: 278. DOI: 10.3389/fnhum.2020.00278.
[24]
Su HH, Fu SS, Liu MC, et al. Altered spontaneous brain activity and functional integration in hemodialysis patients with end-stage renal disease[J]. Front Neurol, 2021, 12: 801336. DOI: 10.3389/fneur.2021.801336.
[25]
Ma C, Tian F, Ma MG, et al. Preferentially disrupted core hubs within the default-mode network in patients with end-stage renal disease: a resting-state functional magnetic resonance imaging study[J]. Front Neurol, 2020, 11: 1032. DOI: 10.3389/fneur.2020.01032.
[26]
Gu ZZ, Lu HT, Zhou H, et al. The relationship between abnormal cortical activity in the anterior cingulate gyrus and cognitive dysfunction in patients with end-stage renal disease: a fMRI study on the amplitude of low-frequency fluctuations[J]. Ann Palliat Med, 2020, 9(6): 4187-4193. DOI: 10.21037/apm-20-2138.
[27]
Chen HJ, Wang YF, Wen JQ, et al. Functional-structural relationship in large-scale brain networks of patients with end stage renal disease after kidney transplantation: a longitudinal study[J]. Hum Brain Mapp, 2020, 41(2): 328-341. DOI: 10.1002/hbm.24804.
[28]
Park BS, Seong M, Ko J, et al. Differences of connectivity between ESRD patients with PD and HD[J]. Brain Behav, 2020, 10(8): e01708. DOI: 10.1002/brb3.1708.
[29]
Zheng SR. Incidence and influencing factors of renal anemia in patients with end-stage renal disease undergoing dialysis[J]. Chin J Tradit Med Sci Technol, 2021, 48(9): 48-50. DOI: 10.3760/cma.j.cn115689-20210119-00263.
[30]
Andro M, le Squere P, Estivin S, et al. Anaemia and cognitive performances in the elderly: a systematic review[J]. Eur J Neurol, 2013, 20(9): 1234-1240. DOI: 10.1111/ene.12175.
[31]
Alagoz S, Dincer MT, Eren N, et al. Prevalence of anemia in predialysis chronic kidney disease: is the study center a significant factor?[J]. PLoS One, 2020, 15(4): e0230980. DOI: 10.1371/journal.pone.0230980.

PREV Study on time variability of brain activity in patients with irritable bowel syndrome with diarrhea based on dynamic amplitude of low-frequency fluctuation
NEXT Resting-state functional magnetic resonance imaging in patients with nocturnal enuresis
  



Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn